5-HIAA in the cerebrospinal fluid. A. Biochemical suicide predictor

ArticleinArchives of General Psychiatry 33(10):1193-7 · November 1976with74 Reads
Impact Factor: 14.48 · Source: PubMed


    The incidence of suicidal acts was studied in 68 depressed patients and related to the level of 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid. The distribution of 5-HIAA levels was bimodal. Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means. Two of the 20 patients in the low mode, and none of the 48 patients in the high mode died from suicide.