Jou YL, Lu TM, Chen YH, et al. Comparison of the predictive value of EuroSCORE, SYNTAX score, and clinical SYNTAX score for outcomes of patients undergoing percutaneous coronary intervention for unprotected left main coronary artery disease

Division of Cardiology, Taipei City Hospital, Yang-Ming Branch, Taipei, Taiwan, Republic of China.
Catheterization and Cardiovascular Interventions (Impact Factor: 2.11). 08/2012; 80(2):222-30. DOI: 10.1002/ccd.23450
Source: PubMed


We aimed to assess the prognostic values of the EuroSCORE, SYNTAX score, and the novel Clinical SYNTAX score (CSS) for 30-day and 1-year outcomes in patients undergoing left main (LM) percutaneous coronary intervention (PCI).
PCI has become an alternative treatment for LM coronary artery disease, and risk scoring system might be beneficial for pre-PCI risk stratification.
We enrolled 198 consecutive patients with unprotected LM disease undergoing PCI (mean age 71.5 ± 10.7 years). The CSS was calculated by multiplying the SYNTAX Score to (age/left ventricular ejection fraction +1 for each 10 mL the estimated glomerular filtration rate <60 mL/min per 1.73 m(2)). The endpoints were 30-day, and 1-year all-cause death and major adverse cardiovascular events (MACE), which were defined as all-cause death, nonfatal MI, and clinical-driven target vessel revascularization. Comparing with the SYNTAX score, the predictive accuracy of CSS for 30-day and 1-year all-cause death and MACE were significantly higher (c-statistics, CSS versus SYNTAX score: P < 0.01 for 30-day and 1-year all-cause death; P < 0.05 for 30-day and 1-year MACE, respectively). Furthermore, in the multivariate Cox regression analysis, both EuroSCORE and CSS were identified as the independent predictors of 30-day and 1-year all-cause death and MACE, but the SYNTAX score was not.
In the general practice among a high-risk population undergoing LM PCI, EuroSCORE and CSS might be independent predictors for 30-day and 1-year all-cause death and MACE. Furthermore, the CSS had a superior discriminatory ability in predicting the 30-day and 1-year clinical outcomes comparing with the SYNTAX score.

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    • "The SYNTAX score was pioneered as an anatomical-based risk score to aid in the decision-making process; the lack of clinical variables in this score has, however, been its main limitation.15)16) A significant improvement in the prediction of cardiac mortality observed after the inclusion of EuroSCORE in a SYNTAX score-based model indicated that clinical and angiographic information are both important for assessing individual risk of patients undergoing left main PCI.17) "
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    ABSTRACT: Background and Objectives The aim of this study was to examine the hypothesis that pentraxin 3 (PTX3) can have a diagnostic value for predicting anatomical complexity of coronary artery stenosis as measured by the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score. Subjects and Methods We investigated the association of systemic arterial PTX3 with SYNTAX score among 500 patients with ischemic heart disease assigned to medical treatment (251), percutaneous coronary intervention (PCI) (197), or coronary artery bypass graft (CABG) (52). Results The clinical judgment of the cardiologists was near-perfectly concordant with the SYNTAX score. Mean {99% confidence intervals (CIs)} SYNTAX scores were 5.8 (5.1-6.6), 18.4 (17.1-19.8), and 33.2 (32.8-33.6) in patients assigned to medical therapy, PCI, and CABG, respectively. The AROC (95% CIs) for discriminating between patients with and without a high SYNTAX score (>23) was 0.920 (0.895-0.946) for systemic arterial levels of PTX3. As the systemic arterial level of PTX3 increased, the SYNTAX scores also increased almost in a curvilinear fashion, with the value corresponding to the SYNTAX score of 23 being 0.29 ng · dL-1. This cutpoint achieved a sensitivity of 0.66 (0.57-0.74), a specificity of 0.94 (0.91-0.96), a positive predictive value of 0.79 (0.70-0.87), and a negative predictive value of 0.89 (0.85-0.92). Conclusion We observed that systemic arterial levels of PTX3 were associated with the SYNTAX score in a curvilinear fashion. The discriminatory power of systemic arterial levels of PTX3 for a high SYNTAX score was excellent. The interesting finding of this study was the near perfect concordance between the decisions made by the cardiologists based on their clinical judgment and the SYNTAX score. The systemic arterial PTX3 level of 0.29 ng · dL-1 was highly specific for diagnosing complex coronary artery stenosis.
    Full-text · Article · Jul 2014 · Korean Circulation Journal
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    • "Syntax score and clinical Syntax score evaluate the risk of PCI, including major adverse cardiac events rates at 1- and 5-year follow-up (all-cause mortality, cardiac death, myocardial infarction and target vessel revascularization).2 In addition, Syntax and clinical Syntax scores are used to evaluate risks of PCI of unprotected LMCA in patients receiving drug-eluting stents.3,4 "
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    ABSTRACT: We report on an octogenarian patient presenting with an acute coronary syndrome due to significant left main coronary artery disease and severe ostial stenosis of the left anterior descending artery disease. Emergent bypass graft performed with "beating heart" consisted of left internal mammary graft to the mid left anterior descending artery with an "over-stent" anastomosis. The immediate post-operative phase was simple, however the patient presented on post-operative day 8 with extensive anterior myocardial infarction and cardiogenic shock. Emergent coronary angiogram showed subocclusive anastomotic stenosis. Percutaneous coronary intervention was performed on left main, proximal left anterior descending, and proximal circumflex arteries. Subsequently, the patient restored a satisfactory hemodynamic condition. A focus on the importance of decision for management of left main disease especially in octogenarian is presented, along with a review of the pertinent literature.
    Full-text · Article · Apr 2013 · Clinical Medicine Insights: Case Reports
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    ABSTRACT: Background The SYNTAX score (SS) is a useful tool for selecting patients with left main or three-vessel coronary artery disease eligible for percutaneous coronary interventions. The score has moderate inter-observer reproducibility among members of the original study. There is not sufficient evidence about the evaluation of the SS by non-interventional cardiologists. Objectives To evaluate whether residents in cardiology can perform an adequate evaluation of the SS and to detect possible biases in this evaluation. Methods Coronary angiographies with evidence of main left coronary artery disease and/or three-vessel disease were retrospectively selected. A resident in cardiology (RC) calculated the total SS in order to compare it with the score calculated by an interventional cardiologist (IC). Data were analyzed using the kappa coefficient (deciles and tertiles), Lin's concordance correlation coefficient and Bland-Altman plot method. Results Ninety three coronary angiographies were analyzed. Mean SS calculated by the IC and the RC were 28.58 (SD 10.0) and 30.44 (SD 10.7), respectively. Mean difference was 1.85 (SD 7.01). The kappa coefficient was 0.57 (0.464-0.678) for deciles and 0.60 for tertiles (0.48-0.72). Lin's coefficient was 0.75 (0.65 to 0.83). The Bland-Altman analysis detected that the RC had a trend towards underestimating high scores calculated by the IC. Conclusions This study demonstrates a moderate to good inter-observer reproducibility between a RC and an IC. This level of agreement is tolerable to calculate the score, as previously published. A trend to underestimate high SS was detected in the RC.
    No preview · Article · Jul 2012 · Revista argentina de cardiología
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