Article

Therapeutic Potential of Quercetin to Decrease Blood Pressure: Review of Efficacy and Mechanisms

Department of Nutrition, Exercise, and Health Science, Central Washington University, Ellensburg, WA, USA.
Advances in Nutrition (Impact Factor: 4.71). 01/2012; 3(1):39-46. DOI: 10.3945/an.111.001271
Source: PubMed

ABSTRACT

Epidemiological studies beginning in the 1990s have reported that intake of quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is inversely related to cardiovascular disease. More recent work using hypertensive animals and humans (>140 mm Hg systolic and >90 mm Hg diastolic) indicates a decrease in blood pressure after quercetin supplementation. A number of proposed mechanisms may be responsible for the observed blood pressure decrease such as antioxidant effects, inhibition of angiotensin-converting enzyme activity, and improved endothelium-dependent and -independent function. The majority of these mechanisms have been identified using animal models treated with quercetin, and relatively few have been corroborated in human studies. The purpose of this review is to examine the evidence supporting the role of quercetin as a potential therapeutic agent and the mechanisms by which quercetin might exert its blood pressure-lowering effect.

Download full-text

Full-text

Available from: Thunder Jalili, Oct 21, 2015
    • "A diet rich in flavonoids can reduce blood pressure, the risk of cardiovascular disease , improves the liver antioxidant defense system and has a beneficial effect on symptoms of neurodegenerative disorders in Parkinson's and Alzheimer's disease (Middleton et al., 2000; Schroeter et al., 2006; larson et al., 2012). Apart from plant sources, these flavonoids are components of supplements in an alternative therapy for the treatment of allergies, asthma, bacterial infections, arthritis, gout, eye disorders , hypertension and neurodegenerative disorders (larson et al., 2012). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Comparative activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), the phase II biotransformation enzyme glutathione-S-transferase (GST), the concentrations of total glutathione (GSH), sulfhydryl groups (-SH) and the activity of the neurotoxicity biomarker acetylcholinesterase (AChE) were investigated in the livers of species belonging to the Pelophylax esculentus “complex” (parental species Pelophylax ridibundus, Pelophylax lessonae, and their hybrid Pelophylax kl. esculentus) from the wetland, Obedska bara in Serbia. The condition factor (CF) and hepato somatic index (HSI) were also calculated. All three species were caught at same locality and were exposed to the same environmental conditions. Liver SOD activity was lower in P. ridibundus than in P. kl. esculentus and P. lessonae; higher activities of CAT, GR and GST were observed in P. kl. esculentus frogs as compared to their parental species. The activity of GSH-Px was significantly lower in P. kl. esculentus. The activity of AChE was increased in P. lessonae as compared to P. kl. esculentus and P. ridibundus. Similar concentrations of GSH and -SH groups were observed in all investigated species. P. kl. esculentus had a higher CF, while the HSI was lower when compared to parental species. Our findings suggest that the parental species (P. ridibundus and P. lessonae) possess more similar antioxidative responses to environmental conditions than the hybrid species P. kl. esculentus. The obtained results improve our understanding of the biology and physiology of these three closely related species.
    No preview · Article · Sep 2015 · Saudi Journal of Biological Sciences
  • Source
    • "Quercetin-type flavonols are widely distributed in plants, and the most abundant forms are quercetin glycosides, which consist of quercetin linked with one or two glucose molecules (Hakkinen et al., 1999). Quercetin has shown many potential benefits to human health such as blood pressure control (Larson et al., 2012), antioxidant, anticancer , antidiabetic, anti-infective, and anti-inflammatory (Kelly, 2011). Besides these beneficial effects on human health, quercetin has also exhibited in vitro antiviral activity against some RNA viruses including the human immunodeficiency virus (HIV), poliovirus type 1, parainfluenza virus type 3, respiratory syncytial virus (Kaul et al., 1985; Kelly, 2011), and hepatitis C (Gonzalez et al., 2009). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Hepatitis B virus (HBV) infection is one of the most serious and prevalent viral diseases in the world. Although several anti-HBV drugs have been used clinically, their side and adverse effects limit treatment efficacy. Therefore, it is necessary to identify novel potential anti-HBV agents. The flavonol quercetin has shown activity against some retroviruses, but its effect on HBV remains unclear. In the present study, quercetin was incubated with HepG2.2.15 cells, as well as HuH-7 cells transfected with an HBV plasmid. Quercetin was shown to significantly reduce Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg), secretion and HBV genomic DNA levels in both cell lines. In addition, co-incubation with lamivudine (3TC), entecavir (ETV), or adefovir (Ade) further enhanced the quercetin-induced inhibition of HBV replication. This inhibition was partially associated with decreased heat shock proteins and HBV transcription levels. The results indicate that quercetin inhibited HBV antigen secretion and genome replication in human hepatoma cell lines, which suggests that quercetin may be a potentially effective anti-HBV agent.
    Full-text · Article · Aug 2015 · Virologica Sinica
  • Source
    • "Moreover, polyphenols have other anti-hypertensive functions beyond their direct antioxidant activity; they promote the induction of detoxifying enzymes, the activation of NO synthase, the reduction in NADPH oxidase activity, and the inhibition of ET-1 expression (Khurana et al., 2013). Among the polyphenols, experimental evidences have shown that quercetin, besides decreasing oxidative stress, may act as an angiotensin-converting enzyme (ACE) inhibitor and may improve the balance between the vasoconstrictor ET-1 and the vasodilator NO (Larson et al., 2012). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Recent studies have shown that DNA damage occurs more often in hypertensive patients than non-hypertensive individuals. Here, we analyzed the in vivo effect of pasta containing 30% of tartary buckwheat sprouts (TBSP) on spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKY) to elucidate if TBSP could have an anti-genotoxic effect in hypertensive animal models. Both SHRs and WKY rats were divided into two groups and fed for six weeks with 5 g of TBSP and durum wheat flour commercial pasta, respectively. Our results showed that a diet rich in TBSP has anti-genotoxic effect. Indeed, SHRs fed with TBSP exhibited a significant decrease in DNA damage (38%) and more efficient DNA repair (84%) compared to SHRs fed with commercial pasta.
    Full-text · Article · Jun 2015 · International Journal of Food Sciences and Nutrition
Show more