Combing the Globe for Terrorism

Department of Neurology and Ophthalmology, State University of New York at Buffalo School of Medicine, Buffalo, NY 14203, USA.
Journal of neuro-ophthalmology: the official journal of the North American Neuro-Ophthalmology Society (Impact Factor: 1.95). 03/2012; 32(1):82-5. DOI: 10.1097/WNO.0b013e31824095d1
Source: PubMed
8 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A 47-year-old man presented with sudden visual loss, optic disc edema, retinal ischemia, and limited upgaze in the left eye. Initial MRI revealed thickened, enhancing left optic nerve. Extensive work up for an inflammatory and infiltrative etiology was positive only for Borrelia burgdorferi IgM by Western blot. Six weeks later the patient had numbness and weakness on his left side. MRI showed enhancing lesions extending from the left optic nerve to the optic chiasm, along the visual pathways bilaterally, mainly on the right side from optic tract to lateral geniculate body and pulvinar. Stereotactic biopsy of the right pulvinar lesion revealed glioblastoma. The tumor progressed rapidly, and the patient died 11 weeks after the onset of first symptoms.
    Full-text · Article · Sep 2014 · Survey of Ophthalmology
  • [Show abstract] [Hide abstract]
    ABSTRACT: Malignant optic glioma of adulthood is a rare, invasive neoplasm of the anterior visual pathway with 66 cases reported in the literature. It presents as anaplastic astrocytoma (WHO grade III) or glioblastoma (WHO grade IV). The present case series covers the spectrum of disease manifestations, discusses neuroradiological findings, and reviews the current literature. Retrospective case series of five patients from three tertiary referral centers and literature review. Visual loss with or without pain was the presenting symptom in all patients (two women, three men). Two patients were initially misdiagnosed as optic neuritis, and one patient as atypical non-arteritic anterior ischemic optic neuropathy (NAION). A neoplastic disease was suspected in the two remaining patients. MRI features were iso- to hypointensity on T1-weighted native images, contrast enhancement, and hyperintensity on T2-weighted images. Biopsy was generally diagnostic; however, one patient required two biopsies for diagnosis. The series includes an exceptional case of intraocular tumor extension and vitreous spread. The disease was lethal within one to two years in all patients. Malignant optic glioma is a diagnostic challenge and remains a devastating and lethal disease. Advances in the understanding of tumor biology have yet failed to translate into effective treatment regimens.
    No preview · Article · May 2015 · Albrecht von Graæes Archiv für Ophthalmologie