Regional and Hemispheric Asymmetries of Cerebral Hemodynamic and Oxygen Metabolism in Newborns

ArticleinCerebral Cortex 23(2) · February 2012with14 Reads
Impact Factor: 8.66 · DOI: 10.1093/cercor/bhs023 · Source: PubMed

    Abstract

    Understanding the evolution of regional and hemispheric asymmetries in the early stages of life is essential to the advancement
    of developmental neuroscience. By using 2 noninvasive optical methods, frequency-domain near-infrared spectroscopy and diffuse
    correlation spectroscopy, we measured cerebral hemoglobin oxygenation (SO2), blood volume (CBV), an index of cerebral blood flow (CBFi), and the metabolic rate of oxygen (CMRO2i) in the frontal, temporal, and parietal regions of 70 premature and term newborns. In concordance with results obtained using
    more invasive imaging modalities, we verified both hemodynamic (CBV, CBFi, and SO2) and metabolic (CMRO2i) parameters were greater in the temporal and parietal regions than in the frontal region and that these differences increased
    with age. In addition, we found that most parameters were significantly greater in the right hemisphere than in the left.
    Finally, in comparing age-matched males and females, we found that males had higher CBFi in most cortical regions, higher CMRO2i in the frontal region, and more prominent right–left CBFi asymmetry. These results reveal, for the first time, that we can detect regional and hemispheric asymmetries in newborns
    using noninvasive optical techniques. Such a bedside screening tool may facilitate early detection of abnormalities and delays
    in maturation of specific cortical areas.