Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations

ArticleinAdvanced drug delivery reviews 64(7):590-7 · January 2012with16 Reads
Impact Factor: 15.04 · DOI: 10.1016/j.addr.2012.01.004 · Source: PubMed


    The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.