Engineering the synchronization of neuron action potentials using global time-delayed feedback stimulation

ArticleinPhysical Review E 84(6 Pt 2):066202 · December 2011with3 Reads
DOI: 10.1103/PhysRevE.84.066202 · Source: PubMed
We experimentally demonstrate the use of continuous, time-delayed, feedback stimulation for controlling the synchronization of neuron action potentials. Phase-based models were experimentally constructed from a single synaptically isolated cultured hippocampal neuron. These models were used to determine the stimulation parameters necessary to produce the desired synchronization behavior in the action potentials of a pair of neurons coupled through a global time-delayed interaction. Measurements made using a dynamic clamp system confirm the generation of the synchronized states predicted by the experimentally constructed phase model. This model was then utilized to extrapolate the feedback stimulation parameters necessary to disrupt the action potential synchronization of a large population of globally interacting neurons.
    • "With the addition of AEC StdpC can now be applied in a majority of dynamic clamp applications that have previously been inaccessible to such experimentation due to the requirements of two independent electrodes. It also allows to reconfirm experiments of authors who have previously used dynamic clamp with single electrodes using only traditional compensation methods of bridge balance and capacitance compensation (Rothman et al., 2009; Rusin et al., 2011). "
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