Article

Quality of Life Measures for Acne Patients

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Box 2473, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
Dermatologic clinics (Impact Factor: 1.69). 04/2012; 30(2):293-300, ix. DOI: 10.1016/j.det.2011.11.001
Source: PubMed

ABSTRACT

Acne vulgaris affects most adolescents and two-thirds of adults and is associated with substantial psychosocial burden. Health-related quality of life (HRQOL) for patients with acne is an important factor of patient care, and several dermatologic and acne-specific measures have been created to assist in acne research, management, and care. This review describes several skin disease and acne-specific HRQOL measures and their applications in clinical care or research. The ideal HRQOL measure for the management of patients with acne is a concise questionnaire that places minimal burden on respondents and allows physicians to track improvement in HRQOL with successful treatment.

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    • "These severe forms of acne frequently heal with disfiguring scars like hypertrophic scars or atrophic scars (Ice pick scars, rolling scars or boxcar scars). Additionally, acne vulgaris may have a psychological impact on any patient regardless of the severity or the grade of the disease (Kellett & Gawkrodger, 1999; Dawson & Dellavalle, 2013; Barnes et al., 2012). Though, we often think that adolescents are more influenced by psychological effects of acne vulgaris, older patients are more bothered by appearance of acne vulgaris and consequently report more effects on their daily lives such as social anxiety, avoidance of activities that bring attention to their condition, embarrassment, poor interpersonal relationship and poor self-image (Layton, 1998; Van der Meeren, Van der Schaar, & Van der Hurk, 1985; Magin et al., 2006; Loney, Standage, & Lewis, 2008; Ogedegbe & Hensaw, 2014; Durai & Nair, 2015). "
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    ABSTRACT: OBJECTIVE: the skin defines the essence of beauty and overall perceived attention within a social context. As such, there is a relationship between skin diseases and the extent of provoked emotional psychological disturbances and social concern that the sufferers do have. This study therefore seeks to ascertain levels of anxiety and their psychosocial consequences among sufferers of acne vulgaris and chronic urticaria in dermatological outpatient in Abuja-Nigeria.MATERIALS/METHODS: this study was a prospective, cross sectional study carried out on consecutive consented dermatological outpatients who had acne vulgaris (N = 62) and chronic urticaria (N = 31) over a period of nine months (June 2013-February 2014) and 50 apparently healthy control matched for age and sex were recruited into the study. Diagnosis of acne vulgaris and chronic urticaria were clinically made. Questions on State Trait Anxiety Index STAI (Y-1) form were used to determine their present feelings and level of perceived anxiety within the society as a result of acne vulgaris and chronic urticaria. Total STAI score greater than 54 suggests severe level of anxiety and univariate analysis of variance was used to determine relationship between anxiety and its social consequences. Data was keyed into and analysed with SPSS 20.RESULTS: ratio of male: female for subjects is 1:1.9 and 1:1.3 for controls while mean age in years ± Standard Deviation (SD) for subjects and controls were 29.02 ± (9.2) and 28.42 ± (8.3) respectively. There was sex and age match between subjects and controls. Also, there was observable moderate to severe anxiety among those that had acne vulgaris and chronic urticaria as compared to apparently healthy controls. Low self-esteem, inferiority complex, lack of self-confidence, and social withdrawal, were among the common social reactions noticeable among the subject group. Mean STAI score ± s.e (standard error) of subjects was significantly higher than that of the controls 49.7 ± 0.788 and 33.9 ± 1.255 respectively at t-test = 11.2 and p = 0.0001.CONCLUSION: acne vulgaris and chronic urticaria was highly associated with moderate to severe anxiety with attending social reactions when compared to apparently healthy controls.
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    • "suggest that the emotional impact of acne is comparable to that experienced by patients with systemic diseases, like diabetes and epilepsy[17]. Most severe forms of acne vulgaris are usually associated with greater quality of life impairment[18]. Acne is a multi-factorial inflammatory skin disease involving both genetic and environmental factors. The latter primarily regard life style and in particular diet habits[19]. "

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    • "It has been clearly shown that acne patients with poor facial skin have reduced quality of life with regard to dissatisfaction about appearance, social bother and even co-morbid depression. It has also been stressed that assessment of quality of life in studies testing any type of agent for facial acne lesions is important and strongly correlates with treatment success [19, 20]. "
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    ABSTRACT: The purpose of this study was to determine the safety, tolerability and effectiveness of daily administration of an orally administered pantothenic acid-based dietary supplement in men and women with facial acne lesions. A randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris was performed. Subjects were randomized to the study agent, a pantothenic acid-based dietary supplement, or a placebo for 12 weeks (endpoint). The primary outcome of the study was the difference in total lesion count between the study agent group versus the placebo group from baseline to endpoint. Secondary measurements included differences in mean non-inflammatory and inflammatory lesions, Investigators Global Assessment and Dermatology Life Quality Index (DLQI) scores between the two groups. Investigator assessment of overall improvement and skin photographs were also taken. Safety and tolerability endpoints were the assessment of adverse events and measurement of serum complete blood count and hepatic function. Forty-eight subjects were enrolled and 41 were evaluable. There was a significant mean reduction in total lesion count in the pantothenic acid group versus placebo at week 12 (P = 0.0197). Mean reduction in inflammatory lesions was also significantly reduced and DLQI scores were significantly lower at week 12 in the pantothenic acid group versus placebo. The study agent was safe and well tolerated. The results from this study indicate that the administration of a pantothenic acid-based dietary supplement in healthy adults with facial acne lesions is safe, well tolerated and reduced total facial lesion count versus placebo after 12 weeks of administration. Secondary analysis shows that the study agent significantly reduced area-specific and inflammatory blemishes. Further randomized, placebo-controlled trials are warranted.
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