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Erratum to “A critical review of the influence of oxytocin nasal spray on social cognition in humans: Evidence and future directions” [Horm. Behav. 61 (2012) 410–418]

Brain & Mind Research Institute, University of Sydney, 2050, Australia.
Hormones and Behavior (Impact Factor: 4.63). 01/2012; 61(3):410-8. DOI: 10.1016/j.yhbeh.2012.01.002
Source: PubMed

ABSTRACT

The past eight years of research has demonstrated that oxytocin nasal spray has a significant impact on human social cognition. The aim of this review is to provide critical comment on the literature using an information-processing framework. We provide a summary of fundamental assumptions of information-processing models and highlight an impressive range of consistent findings that demonstrate the impact of oxytocin nasal spray on social information processing. These findings include that oxytocin nasal spray improves the early conceptual detection of affect from social cues and improves the accurate appraisal of affect from social cues at elaborate and strategic levels of processing. There is some evidence that these effects may be particularly powerful for positive social cues. This review comments on inconsistent results that have been reported. We argue that such inconsistencies can, in part, be explained by variability across experiments in the degree to which potential extraneous confounds have been controlled, the different methods upon which studies assessed cognition, and the extent to which the focus of investigation has been on group-based outcomes. Finally, we argue that sound cognitive experimental methods can provide powerful tools to identify markers of response to oxytocin nasal spray that can be integrated into more complex circuitry models. The identification of robust markers has particular value in predicting behavioral and therapeutic response to intervention. This should now be a major focus for future research. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.

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Available from: Adam J Guastella, Mar 21, 2014
    • "Most important, because the intranasal OT treatment is randomly assigned and always precedes behavior, this method permits valid causal inference (provided that internal validity is established). However, unlike in pharmacological studies of other hormones (e.g., testosterone; Eisenegger, von Eckardstein, Fehr, & von Eckardstein, 2013; Nave, Nadler, & Camerer, 2015), the pharmacokinetics of intranasal OT in humans is not well understood (Churchland & Winkielman, 2012; Guastella et al., 2013; Guastella & MacLeod, 2012; Leng & Ludwig, 2015; Veening & Olivier, 2013). Researchers also lack a simple way to conduct a manipulation check to) is endowed with 12 monetary units (MUs). "
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    ABSTRACT: Behavioral neuroscientists have shown that the neuropeptide oxytocin (OT) plays a key role in social attachment and affiliation in nonhuman mammals. Inspired by this initial research, many social scientists proceeded to examine the associations of OT with trust in humans over the past decade. To conduct this work, they have (a) examined the effects of exogenous OT increase caused by intranasal administration on trusting behavior, (b) correlated individual difference measures of OT plasma levels with measures of trust, and (c) searched for genetic polymorphisms of the OT receptor gene that might be associated with trust. We discuss the different methods used by OT behavioral researchers and review evidence that links OT to trust in humans. Unfortunately, the simplest promising finding associating intranasal OT with higher trust has not replicated well. Moreover, the plasma OT evidence is flawed by how OT is measured in peripheral bodily fluids. Finally, in recent large-sample studies, researchers failed to find consistent associations of specific OT-related genetic polymorphisms and trust. We conclude that the cumulative evidence does not provide robust convergent evidence that human trust is reliably associated with OT (or caused by it). We end with constructive ideas for improving the robustness and rigor of OT research.
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    • "The neuropeptide oxytocin (OT) is synthesized mainly in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus (Buijs, 1978; Sofroniew, 1983), and regulates a wide variety of social behaviors in rodents and humans (Veenema and Neumann, 2008; Heinrichs et al., 2009; Ross and Young, 2009; Goodson and Thompson, 2010; Guastella and MacLeod, 2012). "
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    • "Furthermore, infants express more social behavior(s) in face-to-face interactions when their father receives intranasal OXT than when their father receives placebo, and experience a post-interaction increase in salivary OXT (Weisman et al., 2012). Moreover, intranasal OXT appears to influence several features of social cognition (e.g., face/emotion recognition, judgments of trustworthiness and attractiveness; Graustella and MacLeod, 2012; van IJzendoorn and Bakermans-Kranenburg, 2012). However, these studies on adults examined whether OXT influenced perceptions of other individuals' attractiveness. "
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