Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process

N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Bulletin of Experimental Biology and Medicine (Impact Factor: 0.36). 03/2011; 150(5):632-4. DOI: 10.1007/s10517-011-1208-0
Source: PubMed


We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.

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Available from: Vladimir Vasilievich Sobolev, Apr 20, 2015
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    • "Among epidermal PP-increased DEGs, we identified nine AP-1 binding sites significantly enriched in 2 KB upstream regions (Figure 5). Additionally, in bulk skin biopsies and in LCM-dissected epidermis, expression of genes encoding AP-1 components was significantly altered (e.g., JUNB, FOSL1 and FOS; Additional file 10) [55,56]. These same AP-1 sites, moreover, were similarly enriched in upstream regions of genes induced by IL-17A in KC cultures (also IFN-γ, TNF, IL-20, IL-22 and IL-24; see Figure 5). "
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