Health Protection Agency, Porton Down, Salisbury UK.
Human Vaccines & Immunotherapeutics (Impact Factor: 2.37). 02/2012; 8(2):174-83. DOI: 10.4161/hv.18500
Source: PubMed


Serogroup B meningococcal (MenB) disease remains a serious public health problem for which a cross-protective vaccine effective against a wide range of MenB isolates has not been available. Novartis Vaccines has developed a vaccine for the prevention of MenB disease that contains four antigenic components: factor H binding protein (fHbp), neisserial adhesin A (NadA), Neisseria heparin binding antigen (NHBA) and outer membrane vesicles from a New Zealand epidemic strain (which provides PorA). This vaccine has been submitted for regulatory review in Europe so it is timely to review the design of the vaccine, results to date in clinical studies and the potential strain coverage provided by the vaccine. It is also critical to discuss the key issues for the long-term success of the vaccine which include strain coverage, potential persistence of protection, potential effects on carriage of MenB strains, potential for escape mutants and cost effectiveness.

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    • "location on cell surface) which are then systematically evaluated for capacity to induce the desired immune response/immunogenicity (Rappuoli, 2000). Proof-of-concept for reverse vaccinology was established with Neisseria meningitidis (Pizza et al., 2000), identifying in just 18 months more surface exposed antigens than had been discovered in 40 years of conventional vaccinology; a vaccine based on three of these novel antigens and outer membrane vesicles is now licensed in 30 countries (Gorringe and Pajon, 2012). "
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