Association of PPAR-g gene polymorphisms with obesity and obesity-associated phenotypes in North Indian population

Chatrapati Shahuji Maharaj Medical University, Lucknow, U.P., India.
American Journal of Human Biology (Impact Factor: 1.7). 07/2012; 24(4):454-9. DOI: 10.1002/ajhb.22245
Source: PubMed


The worldwide increasing prevalence of obesity is considered as a major health problem. Peroxisome proliferator-activated receptor gamma (PPAR-γ) controls adipocyte differentiation and regulates a number of genes associated with energy homeostasis. In this study, we investigated the association of PPAR-γ gene Pro12Ala (rs1801282) and C1431T (rs3856806) polymorphisms with morbid obesity and related phenotypes, in north Indian population.
A total of 6,42 subjects, 309, obese and 333 nonobese individuals were included in this case-control study. Insulin, adiponectin, glucose, and lipid levels were estimated using standard protocols. All subjects were genotyped by PCR restriction fragment length polymorphism (PCR-RFLP) method.
The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association. None of the haplotypes showed association with morbid obesity. However, a strong association of variant genotypes was observed with higher levels of insulin, HOMA-IR, and lower serum adiponectin concentrations.
PPAR-γ gene polymorphisms influence obesity and obesity phenotype in a complex manner, probably involving insulin resistance in north Indian population.

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Available from: Jai Prakash, May 31, 2015
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    • "In a previous study[12], we also found that those carrying rs2920502CG and CG/GG genotype had a significantly increased risk of metabolic syndrome and rs4240711GG and AG/GG, rs4842194 CC and CT/CC genotypes were all associated with prominent protective effects for metabolic syndrome. Up to now, numerous studies have focused on the association between C1431T variant (rs3856806) of PPAR-γ and the risk of metabolic syndrome, type 2 diabetes and obesity in several populations[24]–[26], but the conclusions are conflicting. Li et al.[24] reported that polymorphism C1431T of exon 6 of PPAR-γ was associated with metabolic syndrome risks in a Chinese population study of 423 cases with metabolic syndrome and families without metabolic syndrome. "
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