Hypotony in Patients with Uveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Ocular immunology and inflammation (Impact Factor: 1.97). 04/2012; 20(2):104-12. DOI: 10.3109/09273948.2011.647228
Source: PubMed


To assess the prevalence of hypotony in patients with severe forms of uveitis.
The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified.
Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR] = 5.0; p < .01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR = 3.1; p = .03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. <51 years, OR = 0.1; p = .02), in Caucasian patients (OR = 0.1; p < .01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR = 22.9; p < .01).
Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.

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