Pesticides have been widely used since the middle of the twentieth century to protect crops and ensure productivity and safety foods. Herbicides and non‐herbicides, known as insecticides and fungicides are the main categories of used pesticides. In the north hemisphere countries, many fungicides are sprayed, particularly on apple orchards. If most wild apples of Malus sieversii from primeval forests in Tian Shan, China have become scab‐resistant through millions of years, this is not the case of domestic harvested apples from Malus domestica. Apple is the third consumed fruit worldwide. The global culture represents some 71 million tonnes. It was thus interesting to focus on this particular fruit, synonym of the social advancement of middle classes all around the world, and of the development of China. European and American studies pointed out that income, the level of education and the socio‐economic status are determining factors for apple consumption. All middle classes live in the same way, and use the same cultural and food products, claiming their belonging to a way of life different from struggling people. Emerging countries such as Vietnam, Thailand, and Bangladesh, have become important importers. Apple is considered as the perfect healthy fruit, that is worth consuming. In apple, more than 90% of the pesticides sprayed on the surface are located in the epidermis, particularly in the cuticle, a lipidic extracellular biopolymer, that acts as the outermost protective barrier on the surface of the fruit. The chemical composition and the structure of the cuticle are ones of the most important and complex parameters that handle the membrane transport of abiotic molecules such as pesticides. Because the cuticle is biosynthesized, the composition and structure depend mostly on the plant species and varieties, on the different biological development steps, and on diverse abiotic factors including climatic harvesting conditions, or storage conditions. Pesticide formulations contain one or more active molecules and additives whose aim is to promote their penetration and transport through the cuticle. Different chemical groups are responsible for the pesticide activity, and others provide the penetration into the plant target. The physico‐chemical properties of the plant components, active molecules and pesticide formulations, such as amorphous to crystalline ratio of the cuticular waxes, lipophilicity, molecular size, nature of substituents, plasticizers, etc. are key factors to comprehend the location and the transport through the cuticle. Pesticides dissolve and diffuse in a chemically and structurally heterogenous cuticle. As a result, chemical interactions between active molecules and components of the plant cuticle are complex, and as numerous and various as the multiplicity of active molecules, their decay products and plant matrix components.