Article

Antidiarrhoeal Activity of Leaf Extract of Moringa Oleifera in Experimentally Induced Diarrhoea in Rats

International Journal of Phytomedicine 01/2011;

ABSTRACT

To evalauate the antidiarrhoeal activ ity of the hydroalcoholic extract of
moringa oleifera leaves. The hydroalc hoholic extract was evaluated using
rodent animal m odels of diarrhoea like the castor oil and ma gnesium sulfate
induced gastrointestinal motility, in a model of enteropoo ling induced by the
admi nistration of castor oil and PGE2, Charcoal meal test. Acute toxi city
and phytochemi cal constituents were also been evaluated using standardized
methods. The results of the present study indicates that the hydroalcoholic
extract of moringa oleifera leaves wa s effective in inducing a significant
protection against experime ntally induced diarrhoea by castor oil and
magnesium sulfate, as evidenced by a decrease in the numb er of frequency,
weight of stools after 4 hours with respect to control. The extract also
prevented the enteropooling induced by cas tor oil and PGE2 at all the doses
tested. Acute toxicity s tudies indic ated that the extract is saf e till 2500
mg/kg. The antidiarrhoeal activity though, not ascribed to any particular
phytochemi cal present, general tests performed indicated the presence of
flavonoids, tannis which were reported to produce antidiarrhoeal activity.
These results showed that Moringa ol eifera leaves posse ss anti-diarrheal
properties mediated through inhibition of hyper secretion and
gastrointe stinal mo tility that substantiate its use in the treatm ent of diarrhea
in traditiona l me dicines or folklore us e.

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Available from: Lakshmi Narayana Manjunath
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