Conference Paper (PDF Available)

Correlating Clinical Scores with Anatomical Electrodes Locations for Assessing Deep Brain Stimulation

DOI: 10.1007/978-3-642-21504-9_11 Conference: Information Processing in Computer-Assisted Interventions - Second International Conference, IPCAI 2011, Berlin, Germany, June 22, 2011. Proceedings
Source: DBLP


Movement disorders in patients with Parkinson’s disease may require functional surgery, when medical therapy isn’t effective.
In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic
Nucleus (STN). This paper describes successive steps for constructing digital atlases gathering patient’s location of electrode
contacts and clinical scores. Three motor and three neuro-psychological scores were integrated in the study. Correlations
between active contacts localization and clinical data were carried out using an adapted Hierarchical Ascendant Classification
and have enabled the extraction of clusters aiming to suggest optimum sites for therapeutic STN DBS. The postero-superior
region has been found to be effective for motor score improvement whereas the antero-inferior region revealed noticeable neuro-psychological
scores deterioration. Comparison with existing results has shown that such atlases are very promising for understanding phenomena

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Available from: Florent Lalys, Jan 08, 2014