Conference Paper

The virtual physiological human: Challenges and opportunities

Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna
DOI: 10.1109/ISBI.2006.1625042 Conference: Proceedings of the 2006 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Arlington, VA, USA, 6-9 April 2006
Source: DBLP


This paper summarises the current achievements and future developments of the virtual physiological human (VPH) technology. The VPH is an organised collection of computational frameworks and ICT-based tools for the multilevel modelling and simulation of the human anatomy and physiology. Once sufficiently developed, the VPH will provide an essential technological infrastructure to the Physiome Project, to pathology-specific initiatives in translational research, and to vertical solutions for the biomedical industry

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    • "Many other human related fields like anthropology, sociology and psychology, biology, anatomy should be involved to get one's comprehensive, appropriate counterpart. The Virtual Physiological Human provides a methodological and technological framework to enable collaborative investigation of the human body as a single complex system [24]. It tries to involve anatomical, physiological and pathological data to help investigation, which can be taken into consideration for our Cyber-I construction. "
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    ABSTRACT: The investigation of the behaviour of complex numerically simulated systems in response to key control parameters is an important topic in e-Science. One method of investigating such systems is via computational steering, where a scientist or group of scientists changes (steers) the value of control parameters as the simulation is evolving. If such simulations are run over multiple sessions they create complex data structures which can be described as steering \trees". In this paper we investigate a proposed method for reducing the cost of managing steering trees and describe a reference model simulation which oers the potential of comparing the eciency of dierent methods of managing such steering trees.
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    ABSTRACT: The Virtual Physiological Human (VPH) is an initiative, strongly supported by the European Commission (EC), that seeks to develop an integrated model of human physiology at multiple scales from the whole body through the organ, tissue, cell and molecular levels to the genomic level. VPH had its beginnings in 2005 with informal discussions amongst like-minded scientists which led to the STEP project, a Coordination Action funded by the EC that began in early 2006. The STEP project greatly accelerated the progress of the VPH and proved to be a catalyst for wide-ranging discussions within Europe and for outreach activities designed to develop a broad international approach to the huge scientific and technological challenges involved in this area. This paper provides an overview of the VPH and the developments it has engendered in the rapidly expanding worldwide activities associated with the physiome. It then uses one particular project, the Living Human Project, to illustrate the type of advances that are taking place to further the aims of the VPH and similar initiatives worldwide.
    Full-text · Article · Nov 2008 · The Journal of Physiological Sciences
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