Digital Signal Processing Techniques for Gene Finding in Eukaryotes

Conference Paper · July 2008with5 Reads
DOI: 10.1007/978-3-540-69905-7_17 · Source: DBLP
Conference: Image and Signal Processing - 3rd International Conference, ICISP 2008, Cherbourg-Octeville, France, July 1-3, 2008, Proceedings


    In this paper, we investigate the effects of window shape and length on a DFT-based method for gene and exon prediction in
    eukaryotes. We then propose a new gene finding method which combines the selected time-domain and frequency-domain methods,
    by employing the most effective DNA symbolic-to-numeric representation examined to date in conjunction with suitable window
    shape and length parameters and a signal boosting technique. It is shown herein that the new method outperforms major existing
    approaches. By comparison with the existing methods, the proposed method reveals relative improvements of 15.1% to 55.9% over
    different methods in terms of prediction accuracy of exonic nucleotides at a 5% false positive rate using the GENSCAN test