Immunotherapy of rheumatic diseases based on understanding genetic predisposition to the development of these diseases

ArticleinRheumatic Disease Clinics of North America 18(4):915-26 · December 1992with2 Reads
Impact Factor: 2.69 · Source: PubMed


    During the past two decades, investigators have made great inroads in understanding markers of genetic predisposition to the development of rheumatic diseases. An important question that must be addressed by investigators and clinicians is whether this knowledge will ultimately benefit patients, either through genetic counseling or predictions for beneficial therapeutic intervention. This article discusses various disease mechanisms and modes of immunotherapy such as anti-CD4, major histocompatibility complex blockade, and T-cell receptor-based and determinant-induced responsiveness.