Left ventricular functional response to moderate and intense exercise.

School of Physical and Health Education, University of Toronto, Ontario.
Canadian journal of sport sciences = Journal canadien des sciences du sport 10/1991; 16(3):204-9.
Source: PubMed


The left ventricular (LV) volume and ejection fraction (EF) response to upright exercise was assessed on 15 normal subjects during cycle ergometry. Measures of cardiac function and gas exchange were made at rest, at 85% of the ventilatory anaerobic threshold (VAT; WL1), and at peak exercise (WL2). EF increased from rest (58 +/- 12%) during WL1 (66 +/- 10%), reaching significantly higher values at WL2 (69 +/- 8%; p less than .05). End-diastolic volume increased from rest during WL1 (136 +/- 36 ml vs. 118 +/- 32 ml; p less than .05), becoming significantly higher than rest during WL2 (141 +/- 41 ml). End-systolic volume was unchanged from rest (51 +/- 25 ml) during submaximal exercise (50 +/- 20 ml), but it decreased significantly during WL2 (44 +/- 21 ml; p less than .05). The systolic pressure/end-systolic volume ratio increased from 3.0 +/- 1.7 (rest) to 5.8 +/- 3.0 at WL2 (p less than .05). These results suggest that the Frank-Starling mechanism is operative throughout exercise, particularly during exercise below the VAT. LV performance after the VAT is further augmented by increased contractility with continued, yet diminished, utilization of the Frank-Starling mechanism.

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    • "The constant E/E a indicates a constant filling pressure, and thus no indication of Frank–Starling mechanism. E/E a ratio is slightly higher than in previous studies [9] [10] , as tissue velocity is by colour Doppler [25] . The lack of evidence of the Frank– Starling effect in this group of young males is in accordance with Gerstenblith et al. [19] . "
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