Right hemisphere dominance of different mismatch negativity

Department of Psychology, University of Helsinki, Finland.
Electroencephalography and Clinical Neurophysiology 07/1991; 78(6):466-79. DOI: 10.1016/0013-4694(91)90064-B
Source: PubMed


Auditory stimulus blocks were presented to 10 reading subjects. Each block consisted of 2 types of stimulus, standard (P = 90%) and deviant (P = 10%), delivered in a random order with short constant inter-stimulus intervals. The standard stimuli were 600 Hz. 80 dB SPL 50 msec sine wave bursts. In different blocks, the deviant stimuli differed from the standards either in frequency (650 Hz), intensity (70 dB) or duration (20 msec). Left- and right-ear stimulations were used in separate blocks. Event-related brain potentials (ERPs) were recorded with 16 electrodes over both hemispheres. All the different types of deviant stimuli elicited an ERP component called the mismatch negativity (MMN). The MMN was larger over the right hemisphere irrespective of the ear stimulated whereas the N1 component, elicited by both standards and deviants, was larger over the hemisphere contralateral to the ear stimulated. The results provide further evidence for the view that the MMN reflects a neural mismatch process with a memory trace which automatically codes the physical features of the repetitive stimuli.

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    • "As such, an MMN design allows the examination of amplitude differences upon the detection of a change between standard and deviant pronunciations. Since its discovery in the 1970s (Näätänen et al., 1978), MMN has been linked to various aspects of deviant acoustic properties (for an overview, seeShtyrov and Pulvermüller, 2007) such as pitch (e.g.,Näätänen and Gaillard, 1983;), stimulus duration (Paavilainen et al., 1991), and loudness (e.g.,Keidel and Spreng, 1965). It has been shown that better discrimination of a native or a non-native phonetic contrast is reflected by higher MMN amplitudes (e.g.,Winkler et al., 1999;Shafer et al., 2004).Näätänen et al. (1997)were among the first to observe such language-specific phoneme representations using MMN. "
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    ABSTRACT: The Mismatch Negativity (MMN) response has often been used to measure memory traces for phonological representations and to show effects of long-term native language (L1) experience on neural organization. We know little about whether phonological representations of non-native (L2) phonemes are modulated by experience with distinct non-native accents. We used MMN to examine effects of experience with L2-accented speech on auditory brain responses. Specifically, we tested whether it is long-term experience with language-specific L2 pronunciations or instead acoustic similarity between L2 speech sounds that modulates non-native phoneme perception. We registered MMN responses of Dutch and German proficient L2 speakers of English to the English interdental fricative /θ/ and compared it to its non-native pronunciations /s/ (typical pronunciation of /θ/ for German speakers) and /t/ (typical pronunciation of /θ/ for Dutch speakers). Dutch and German listeners heard the English pseudoword thond and its pronunciation deviants sond and tond. We computed the identity Mismatch Negativity (iMMN) by analyzing the difference in ERPs when the deviants were the frequent versus the infrequent stimulus for the respective group of L2 listeners. For both groups, tond and sond elicited mismatch effects of comparable size. Overall, the results suggest that experience with deviant pronunciations of L2 speech sounds in foreign-accented speech does not alter auditory memory traces. Instead, non-native phoneme perception seems to be modulated by acoustic similarity between speech sounds rather than by experience with typical L2 pronunciation patterns.
    Full-text · Article · Jan 2016 · Frontiers in Psychology
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    • "In agreement with the source localisation (Fig. 6d), PGC analysis consistently disclosed two major bilateral signal propagations close to the primary auditory cortex in both the right and left temporal areas. The average of PGC values across subjects reveal greater activity in the bilateral temporal region, consistent with previous studies (Paavilainen et al. 1991; Kaiser et al. 2000; Stevens et al. 2005). The PGC measure also suggests specific directionality of cortical interactions, which in turn reveals evidence of the underlying neural mechanisms. "
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    ABSTRACT: Partial Granger causality (PGC) has been applied to analyse causal functional neural connectivity after effectively mitigating confounding influences caused by endogenous latent variables and exogenous environmental inputs. However, it is not known how this connectivity obtained from PGC evolves over time. Furthermore, PGC has yet to be tested on realistic nonlinear neural circuit models and multi-trial event-related potentials (ERPs) data. In this work, we first applied a time-domain PGC technique to evaluate simulated neural circuit models, and demonstrated that the PGC measure is more accurate and robust in detecting connectivity patterns as compared to conditional Granger causality and partial directed coherence, especially when the circuit is intrinsically nonlinear. Moreover, the connectivity in PGC settles faster into a stable and correct configuration over time. After method verification, we applied PGC to reveal the causal connections of ERP trials of a mismatch negativity auditory oddball paradigm. The PGC analysis revealed a significant bilateral but asymmetrical localised activity in the temporal lobe close to the auditory cortex, and causal influences in the frontal, parietal and cingulate cortical areas, consistent with previous studies. Interestingly, the time to reach a stable connectivity configuration (~250-300 ms) coincides with the deviation of ensemble ERPs of oddball from standard tones. Finally, using a sliding time window, we showed higher resolution dynamics of causal connectivity within an ERP trial. In summary, time-domain PGC is promising in deciphering directed functional connectivity in nonlinear and ERP trials accurately, and at a sufficiently early stage. This data-driven approach can reduce computational time, and determine the key architecture for neural circuit modelling.
    Full-text · Article · Oct 2015 · Neuroinformatics
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    • "[Doeller et al., 2003; Inui et al., 2006; Opitz et al., 1999; Sch€ onwiesner et al., 2007; Yvert et al., 2001]. Consistent with sensor-level data and previous findings, MMNm was larger on the right hemisphere [Paavilainen et al., 1991; Recasens et al., 2014]. Similarly, left-and right-ward lateralization of deviance-related effects in the Nbm and Pbm components, respectively, was in agreement with sensorlevel data. "
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    ABSTRACT: Our auditory system is able to encode acoustic regularity of growing levels of complexity to model and predict incoming events. Recent evidence suggests that early indices of deviance detection in the time range of the middle-latency responses (MLR) precede the mismatch negativity (MMN), a well-established error response associated with deviance detection. While studies suggest that only the MMN, but not early deviance-related MLR, underlie complex regularity levels, it is not clear whether these two mechanisms interplay during scene analysis by encoding nested levels of acoustic regularity, and whether neuronal sources underlying local and global deviations are hierarchically organized. We registered magnetoencephalographic evoked fields to rapidly presented four-tone local sequences containing a frequency change. Temporally integrated local events, in turn, defined global regularities, which were infrequently violated by a tone repetition. A global magnetic mismatch negativity (MMNm) was obtained at 140-220 ms when breaking the global regularity, but no deviance-related effects were shown in early latencies. Conversely, Nbm (45-55 ms) and Pbm (60-75 ms) deflections of the MLR, and an earlier MMNm response at 120-160 ms, responded to local violations. Distinct neuronal generators in the auditory cortex underlay the processing of local and global regularity violations, suggesting that nested levels of complexity of auditory object representations are represented in separated cortical areas. Our results suggest that the different processing stages and anatomical areas involved in the encoding of auditory representations, and the subsequent detection of its violations, are hierarchically organized in the human auditory cortex. Hum Brain Mapp, 2014. © 2014 Wiley Periodicals, Inc.
    Full-text · Article · Nov 2014 · Human Brain Mapping
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