Extrauterine mixed mesodermal tumors. An immunohistochemical study

ArticleinArchives of pathology & laboratory medicine 115(9):918-20 · October 1991with4 Reads
Source: PubMed
Mixed mesodermal tumors are uncommon outside the uterus. Nine extrauterine mixed mesodermal tumors (eight ovarian and one extragenital) were selected for histochemical and immunoperoxidase study. In eight cases, both epithelial and mesenchymal elements were malignant (chondroid in six, rhabdomyoid in four, and osteoid in two). One ovarian tumor was an adenosarcoma. All cases were stained with periodic acid-Schiff with and without diastase and for alpha 1-antitrypsin, myoglobin, keratin, vimentin, muscle-specific actin, and alpha 1-antichymotrypsin, by using the avidin-biotin-immunoperoxidase method. The periodic acid-Schiff-positive, diastase-resistant droplets in several of the tumors showed peripheral alpha 1-antitrypsin positivity. Keratin delineated epithelial areas well in seven cases, and rhabdomyoid differentiation was confirmed with myoglobin in four cases. However, squamous elements in one tumor were falsely positive for myoglobin. We concluded that despite occasional cross-reactivity, carefully interpreted immunoperoxidase stains can be useful in distinguishing epithelial and mesenchymal elements in these tumors.
    • "Since that time, hundreds of similar cases have been reported in several series in the literature, most of which include a small number of patients and only one reports on up to 100 cases [2]. More than sixty histologically similar ovarian tumors have been described during the past 30 years23456789101112. In the biggest series ever to be reported [3], Eichborn et al. studied 40 patients with ovarian mesodermal adenosarcoma of grades Ia–IIIb according to FIGO classification system. "
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