Toxic cannabis psychosis is a valid entity

ArticleinSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 78(8):476-81 · November 1990with111 Reads
Impact Factor: 1.63 · Source: PubMed

One hundred black men admitted to hospital with acute psychiatric symptoms were investigated for the presence of urinary cannabis metabolites in order to delineate the psychiatric role played by 'dagga', the potent South African cannabinol, in the study population and to determine the diagnostic value of the entity 'toxic psychosis (dagga)'. Cannabinoids were present in 29% of patients, and 31% were discharged with a diagnosis of toxic psychosis (dagga). Clinical and demographic material was gathered for all patients and no consistent differences were found between dagga-positive and dagga-negative patients or toxic dagga psychotic patients and 'functional' psychotics other than a history of recent dagga use and the dagga screening test result. The latter measure was found to be both more sensitive and more specific than the history of dagga use alone. The findings support the routine use of a simple screening test for dagga in the sample population studied. The study demonstrated the heterogeneous nature of the toxic dagga psychosis syndrome by documenting a variety of different clinical presentations, which included schizophrenia (42%), paranoia (26%), maniform psychosis (16%) and organic psychosis (16%).


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    • "Withdrawal status may also be involved in the fourth factor ('panic-anxiety'), due to the overlap between anxiety and withdrawal symptomatology, and shared features in terms of neurobiology and physiopathology333435. The third dimension ('sensitivity-psychoticism') may be understood in the light of self-treatment theory, as the consequence of the antipsychotic action of opioids3637383940414243 or as a consequence of a concomitant abuse of stimulants or cannabis444546474849505152. The last dimension ('violence-suicide') is marked by impulsiveness , which is a major feature of addictive behaviour , as can be explained by the common neurobiological background, involving the limbic system and prefrontal cortex, and risk factors, such as antisociality and drugrelated disinhibition535455565758596061. "
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    • "The CBD content of cannabis varies and lower levels of CBD in cannabis have been associated with higher rates of psy- chosis1920212223. For example, a variant of South African cannabis that is nearly devoid of CBD is associated with higher rates of psychosis [21, 23, 24]. Of note, CBD has been shown to inhibit the psychotomimetic effects of THC [25@BULLET@BULLET, 26]. "
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    Full-text · Article · Jun 2014
    • "In fact, the majority of psychotic subjects who develop opioid addiction are more likely to be diagnosed as suffering from borderline pictures, intermittent psychotic disorders such as bipolar I, or atypical pictures including substance-induced psychosis. Also, given the high rate of current polyabuse of psychotomimetic drugs, such as cannabis, mild psychotic syndromes may be frequent on psychometric grounds, even when underrated on clinical grounds4243444546. Lastly, the fifth psychological/psychiatric dimension shown by opioid addicts on treatment entry is most easily identified through by violent acting outs and features of self-directed aggressiveness. "
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    Full-text · Article · Apr 2010 · Annals of General Psychiatry
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