Bacterial Meningitis in the United States, 1986: Report of a Multistate Surveillance Study

ArticleinThe Journal of Infectious Diseases 162(6):1316-23 · January 1991with10 Reads
Impact Factor: 6.00 · DOI: 10.1093/infdis/162.6.1316 · Source: PubMed


    A prospective, laboratory-based surveillance project obtained accurate data on meningitis in a population of 34 million people
    during 1986. Haemophilus inftuenzae was the most common cause of bacterial meningitis (45%), followed by Streptococcus pneumoniae (18%), and Neisseria meningitidis (14%). Rates of H. inftuenzae meningitis varied significantlybyregion, from 1.91100,000 in New Jersey to 4.0/100,000 in Washington state. The overall case
    fatality rates for meningitis were lower than those reported in several studies from the early 1970s, suggesting that improvements
    in early detection and antibiotic treatment may have occurred since that time. Concurrent surveillance was also performed
    for all invasive disease due to the five most common causes of bacterial meningitis. Serotypes of group B streptococcus other
    than type III caused more than halfof neonatal group B streptococcal disease and mortality, suggesting that an optimal vaccine
    preparation must be multivalent. Of the organisms evaluated, group B streptococcus was the second most common cause of invasive
    disease in persons >5 years old.