A Simple, Effective Method of Treating Vertigo Patients

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Medical treatment of vertigo even today is far from satisfactory. A controlled clinical trial of treating vertigo patients by 1% ephedrine hydrochloride nasal douche has been conducted in 84 patients; 74.3% patients were either completely or partially relieved of their dizziness. The therapy was well accepted by patients and side effects were minimal.

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... The use of amphetamines in combination with scopolamine or antihistaminics increased the antivertiginous effect and reduced the secondary sedation produced by antihistaminics and anticholinergic drugs. Ephedrine (α-and βreceptor agonist) seems to be effective in the vertigo treatment [20]. ...
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This work reviews the neuropharmacology of the vestibular system, with an emphasis on the mechanism of action of drugs used in the treatment of vestibular disorders. Clinicians are confronted with a rapidly changing field in which advances in the knowledge of ionic channel function and synaptic transmission mechanisms have led to the development of new scientific models for the understanding of vestibular dysfunction and its management. In particular, there have been recent advances in our knowledge of the fundamental mechanisms of vestibular system function and of drug action. In this work, drugs acting on vestibular system have been grouped into two main categories according to their primary mechanisms of action: those with effects on neurotransmitters and neuromodulators dynamics and those that act on voltage-gated ion channels. Particular attention is given in this review to drugs that may provide additional insight into the pathophysiology of vestibular diseases. The critical analysis of the literature reveals that there is a significant lack of information defining the real utility of diverse drugs used in clinical practice. The development of basic studies addressing drug actions at the molecular, cellular and systems level, combined with reliable and well controlled clinical trials, would provide the scientific basis for new strategies for the treatment of vestibular disorders.
Radionuclide imaging of sodium pertechnetate 99m sprayed intranasally with a gloss atomizer has shown that the bulk of the isotope is deposited in the olfactory region in both monkeys and man. Ultrastructural studies on the olfactory mucosa from rhesus monkeys in which colloidal gold was sprayed into the nostrils revealed that these particles enter both the olfactory neurons and the supporting cells. Particles entering the neurons could be traced as far as the fila olfactoria and those entering the supporting cells end up in the blood vessels on which these cells abut. The present studies reveal that the intranasal route can be used for administering drugs directly into the brain as well as into the systemic circulation. The feasibility of the route for wider therapeutic usage needs to be further tested.
THE importance of various brain structures in the regulation of secretion of gonadotropins1-3 and the presence of steroid hormones in the cerebrospinal fluid (CSF)4-5 suggest that a method for delivering steroids into the CSF might be useful in the control of fertility. Steroids can enter the cerebral components rapidly after intranasal administration and their concentrations are higher than after intravenous injection6. We report here that progesterone and norethisterone given intranasally can prevent ovulation in rhesus monkeys.
• On the basis of our clinical experience, it has been noted that an unusually large proportion of patients with Meniere's disease have intermittent eustachian tube blockage. A review of the tympanograms of 81 patients with Meniere's disease, representing 107 ears, showed that 25 (30.9%) of the patients and 35 (32.7%) of the ears had abnormal negative middle ear pressure. The maximum compliance peak was in at a pressure point in excess of −100 mm H2O. Further investigation of these patients has led us to conclude that intermittent eustachian tube blockage frequently accompanies Meniere's disease, yet it is not necessarily the cause of the symptomatic disorder. (Arch Otolaryngol 103:355-357, 1977)
Spraying estradiol-17β, progesterone or norethisterone intranasally in adult male rhesus monkeys (7.5-11 kg BW) at a daily dose of 30 µg/day for a period of 60 days resulted in a decrease of testicular size, arrest of spermatogenesis and a significant reduction in serum levels of testosterone. No changes were observed in the solvent-treated controls.
A routine X-ray examination of the sinuses of a patient complaining of regular bouts of dizziness may provide diagnostic information about a so-called sinugenic vertigo. In addition to the pathological X-ray findings in the maxillary sinuses, the patients presented either a positioning nystagmus or a head-shaking nystagmus, with disturbed vestibular spinal reaction as a pathological vestibular condition. Out of 15 patients in whom a sinusitis-induced (sinugenic) dizziness was diagnosed and who appeared regularly for the control checks, 14 patients said that they were relieved of the dizziness as a result of sinus therapy, often immediately afterwards. Interrelationships possibly exist between pathological trigeminus reflexes via the sphenopalatine ganglion brought about by maxillary sinusitis and a reflectory labyrinthine irritation, triggering the vertigo.
Uptake and radioactivity by body fluids and tissues in rhesus monkeys after intravenous injection or in tranasal spray of tritium labelled estradiol and progesterone.
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