Article

Neat reaction technology for the synthesis of 4-Oxo-thiazolidines derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized 4-thiazolidinones

Journal of the Iranian Chemical Society (Impact Factor: 1.09). 09/2006; 3 (3):233-241. DOI: 10.1007/BF03247213

ABSTRACT

The synthesis of 4-thiazolidinones 4a-j in a good yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N’-benzylideneacetohydrazide 3a-j with SHCH2COOH in DMF in the presence of a catalytic amount of anhydrous ZnCl2 under microwave irradiation is described and compared with conventional synthesis methods. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Some of the new compounds were tested against bacteria (Gram- ve and Gram+ ve) and fungi.

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    • "Microwave irradiation (MW) has emerged as a powerful technique offering simple, clean, fast, efficient, and economical method for the synthesis of a large number of biologically active molecules [1–6]. The application of microwave irradiation in organic synthesis has been the focus of considerable attention in recent years and is becoming an increasingly popular technology [7–14]. "
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    • "2012; 80: 789–823 microwave and conventional methods using ZnCl 2 as a catalyst. The synthesized compounds were screened for their in vitro antimicrobial activities [88]. Screening results revealed significant inhibitory activity (inhibition zone 20–25 mm) of derivatives having a 2-OCH 3 -C 6 H 4 group at second position of the thiazolidine ring against Escherichia coli, Candida albicans, and Candida parapsilosis, whereas derivatives bearing 4-NO 2 -C 6 H 4 , 2-OH-C 6 H 4 , 4-OH-C 6 H 4 , 4-OCH 3 -C 6 H 4 , 2-Cl-C 6 H 4, and 4-Cl-C 6 H 4 groups were found to have moderate activity (inhibition zone 15–20 mm) against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. "
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