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Effect of homeopathic treatment on fibrositis (primary fibromyalgia)

Authors:
seen
on
further
ultrasonography
and
in
biopsy
speci-
mens.
Several
treatments
were
required
for
each
tumour,
and
injecting
alcohol
was
often
associated
with
considerable
pain,
whereas
our
patients
did
not
report
pain.
These
reports
did
not
mention
changes
seen
on
ultrasound
scans
during
or
immediately
after
injection,
which
we
found
useful
in
laser
treatment.
The
most
important
advantage
of
the
laser
is
its
precision.
It
is
unlikely
that
it
will
ever
be
possible
to
predict
the
extent
of
necrosis
around
a
site
at
which
absolute
alcohol
has
been
injected
with
an
accuracy
comparable
to
that
already
possible
with
the
laser
technique.
In
conclusion,
interstitial
laser
hyperthermia
is
feasible
and
seems
to
be
safe.
A
multiple
fibre
system
makes
it
feasible
to
treat
tumours
of
clinically
relevant
size
in
the
centre
of
solid
organs.
The
real
challenge
for
the
future
will
be
to
develop
diagnostic
techniques
that
disclose
exactly
how
far
individual
tumours
extend
in
a
wider
range
of
organs
(unlike
the
well
defined
tumours
treated
in
this
pilot
study)
and
to
establish
the
conditions
of
laser
treatment
that
give
complete
tumour
ablation
with
safe
healing.
This
combination
of
technologies
may
be
valuable
for
treating
otherwise
untreatable
tumours
in
a
range
of
solid
organs
and
for
the
primary
treatment
of
small
neoplasms
such
as
tumours
of
the
prostate
and
adrenal
glands.
We
thank
Mr
R
C
G
Russell,
Mr
P
Hawley,
Mr
W
Slack,
and
the
late
Professor
C
G
Clark
for
referring
these
patients
and
for
permission
to
report
these
results.
We
also
thank
Dr
T
N
Mills,
Mr
P
Hill,
and
Miss
L
A
Potter
of
the
department
of
medical
physics
for
their
help.
Mr
Steger
was
supported
by
Living
Technology
Ltd,
Glasgow,
and
Dr
Bown
by
the
special
medical
development
on
lasers
from
the
Department
of
Health
and
by
the
Imperial
Cancer
Research
Fund.
1
Storm
KF,
Kaiser
L-R,
Goodnight
JE,
ei
al.
*Fhermotherapy
for
melanoma
metastascs
in
liser.
Cancer
1982;49:
1243-s.
2
Lindholm
C-E,
K'ellan
E,
Nilson
P,
Hertzman
S.
Microwave
indtuccd
hy-perthermia
and
radiotherapy
in
human
superficial
tumotirs
clinical
results
with
a
comparative
study
of
combined
treatment
versus
radiothcrapy
alone.
lnr,7
s'p
1erpthermia
1987;3:393-41
1.
3
Milligan
AJ.
Whole
body
hypcrthertmia
iinductioni
tcchniqtucs.
Cancer
Res
1984;44
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Suppl):4869-72.
4
Shiplc
WU,
Nardi
GL,
Cohen
AM,
Cliftoin
Ling
C.
Iodine-'"'
implant
and
cxtcrnal
bceam
irradiation
in
patienits
with
localized
pancreatic
carciinoma.
Cancer
19X0;45:709-14.
5
Dritclilo
A,
(irant
EG,
Harter
KW;,
Holt
RWY,
Rustigi
SN,
Rodgers
JE.
Intcrstitial
radiation
therapy
for
hcpatic
metastases:
sonographic
guidance
for
applicator
placement.
Am,7
Radtol
1986;164:275-8.
6
Bown
SG.
Phototherapy
of
tumors
World.7
Surg
1983;7:700-9.
7
Matthewson
K,
Coleridge-Smith
1,
O'Sullisan
JP,
Northfield
PIC,
Bown
SG.
Biological
effects
of
intrahepatic
Nd-YAG
lascr
photocoagulation
in
rats.
Gastrosnicrologv
987;93:550-7
8
Stcger
AC,
Bown
SG,
Clarke
C(G
Intcrstitial
lascr
hypcrthermia-stttdics
in
the
nortmal
liver.
fBrj
Surg
1988;75:59X
9
Mlatthewson
K,
Coleridge-Smith
1P,
Northlfield
I,,
Bowil
SG.
Cotoparisonl
of
contintUoUs
uave
attd
puIlsed
excitationi
for
interstitial
Nd-YA(
iidttdccd
hvprthermia.
lasers
inn
Medical
Sciunce
1986;1
197-201.
10
Hashimoto
1).
Ultrasonography
guidcd
lasers
and
sphcric
lasers.
In:
Ricmann
JF,
Ell
C,
cds.
Lasers
in
gastrocnicrologs'
Gec)rg
Thiemc
V'crlag
Inc,
Stuittgart:
Thicmc
P'uLblishicrs,
1989:134-8.
11
Godlewski
(i,
Sambtc
P,
Eledjam
JJ,
Pignodel
C,
Ould-Said
A,
Bourgeois
JM.
A
new
device
ftr
inducing
deep
localised
vaptrisation
in
liver
with
the
Nd-
YAG
laser.
lasers
inM
edical
Science
19XX;3:
111-7.
12
Shiina
S,
Yasuda
H,
Aluto
H,
et
al.
P'ercutaneous
ethanol
iijectioin
in
the
treatment
of
liser
neoplasms.
Amj7
Radiol
1987;149:949-52.
13
Livraghi
T,
Fcsti
Ml,
Monti
F,
Salmi
A,
Vcttori
C.
US-guidcd
pcrCutatlcous
alcohol
iIjectioIn
of
small
hepatic
aind
abdomiial
tuimiors.
Radiology
1986;161
:3(9-12.
(A.4septsd31
.IlaY
1919
Departments
of
Rheumatology
and
Clinical
Pharmacology,
St
Bartholomew's
Hospital,
London
ECIA
7BE
Peter
Fisher,
FFHOM,
visitintg
rheumatologist
Alison
Greenwood,
SRN,
clinical
metrologist
E
C
Huskisson,
FRCP,
head
of
rheumatolopv
department
Paul
Turner,
FRCIP,
projfessor
of
clinical
pharmtacology
Laboratoires
Boiron,
69110
Ste
Foy
les
Lyon,
France
Philippe
Belon,
MD,
research
director
Correspondence
to:
Dr
Fisher.
BrAfedj
1989;299:365-6
Effect
of
homoeopathic
treatment
on
fibrositis
(primary
fibromyalgia)
Peter
Fisher,
Alison
Greenwood,
E
C
Huskisson,
Paul
Turner,
Philippe
Belon
In
scientific
research
negative
results
are
often
more
difficult
to
interpret
than
positive
ones,
as
was
shown
by
a
clinical
trial
in
which
the
homoeopathic
medicine
Rhus
toxicodendron
6x
was
compared
with
a
placebo
and
fenoprofen
in
the
treatment
of
osteoarthritis.
The
homoeopathic
medicine
was
found
to
be
ineffective
whereas
fenoprofen
gave
an
improvement.'
There
were
two
interpretations:
either
the
effects
of
homoeo-
pathy
are
only
a
placebo
effect-that
is,
a
true
negative
-or
the
result
was
a
false
negative
one
because
of
flaws
in
the
design.
Another
trial
had
previously
suggested
that
homoeopathy
was
effective
in
rheuma-
toid
arthritis.
We
designed
a
trial
to
clarify
these
results
by
overcoming
the
methodological
criticisms
while
retain-
ing
a
rigorous
design.
The
main
problem
in
designing
clinical
trials
of
homoeopathy
is
that
prescriptions
are
based
on
criteria
such
as
the
pattern
of
symptoms
as
well
as
the
diagnosis.
A
clinical
trial
based
solely
on
diagnosis
is
therefore
inappropriate.
In
a
pilot
study
we
had
shown
that
R
toxicodenidron
6c
was
the
most
commonly
indicated
homoeopathic
medicine
for
fibrositis
in
our
patients,
being
indicated
in
42%.
Patients,
methods,
and
results
We
used
the
diagnostic
criteria
of
Yunus
et
al
for
fibrositis.'
Only
patients
with
this
syndrome,
in
whom
the
homoeopathic
medicine
R
toxicodendron
6c
was
positively
indicated
were
entered
into
the study.
Thirty
patients
meeting
the
admission
criteria
were
recruited
in
the
rheumatology
clinic
of
this
hospital.
The
clinical
characteristics
of
the
patients
were
similar
to
those
of
other
reported
series
regarding
age,
sex
distribution,
duration
of
symptoms,
modalities,
and
number
of
tender
points.
The
trial
was
double
blind,
placebo
controlled,
and
of
crossover
design.
After
entry
there
was
no
further
contact
between
the
homoeopathic
doctor
and
the
patient
until
the
treat-
ment
was
finished.
The
clinical
metrologist
dispensed
the
treatment
and
performed
the
assessments
and
analyses
blind.
Patients
received
active
treatment
and
an
identical
placebo
for
one
month
each
in
random
sequence.
The
dose
was
two
tablets
sucked
three
times
daily.
The
active
preparation
was
R
toxicodendron
6c
(Boiron)
prepared
from
a
tincture
of
the
leaves
of
poison
oak
diluted
1:99
in
ethanol
and
then
vigorously
shaken.
This
process
was
repeated
six
times
to
give
the
6c
potency-a
dilution
of
102
of
the
tincture.
This
was
then
put
up
on
125
mg
lactose
tablets
(2%
volume
per
weight).
Preparation
was
as
specified
in
the
French
national
pharmacopoeia.
The
placebo
was
identical
lactose
tablets
to
which
only
pharmaceutical
ethanol
had
been
added
(2%
volume
per
weight).
Blind
testing
of
the
active
and
placebo
preparations
for
a
battery
of
drugs
yielded
negative
results.
Assessment
comprised
the
number
of
tender
spots,
10
cm
visual
analogue
scales
of
pain
and
sleep,
and
overall
assessment.
Comparison
was
made
between
values
at
the
end
of
active
and
placebo
treatment
periods.
The
patients
did
better
in
all
variables
when
they
took
active
treatment
rather
than
placebo.
The
number
of
tender
spots
was
reduced
by
about
a
quarter
(p<0005).
We
reduced
subjective
data
to
nominal
measurements
(worse
or
better).
If
the
null
hypothesis
were
correct
the
direction
of
change
after
placebo
and
active
treatment
would
be
randomly
distributed.
Analysis
showed
a
significant
difference
in
favour
of
the
homoeopathic
medicine
(table).
Overall
assess-
ment
also
showed
a
preference
for
the
active
treatment,
which
was
not
significant.
BMJ
VOLUME
299
5
AUGUST
1989
365
Assessment
of
patients
with
fibrositis
after
treatment
with
Rhus
toxicodendron
(ac-tive)
and
placebo
Placebo
Active
p
Value
Mean
No
of
tender
points
14-1
10-6
<0.005*
No
of
patients
with
improved
pain
or
sleep
(visual
analogue
scores)
27
53
0-0052t
*Wilcoxon
rank
sum
test.
tPaircd
t
test.
Comment
Fibrositis
(primary
fibromyalgia)
is
a
controversial
condition
but
is
becoming
increasingly
accepted.4
It
is
difficult
to
treat.
We
showed
that
the
homoeopathic
medicine
R
toxicodendron
6c
was
effective
for
a
selected
subgroup
of
patients
with
fibrositis.
The
improvement
in
tenderness,
which
is
the best
discriminator
of
fibrositis,5
was
particularly
distinct.
The
improvement
experienced
by
our
patients
while
receiving
active
treatment
was
at
least
as
great
as
that
reported
for
any
other
treatment
that
has
been
assessed
double
blind.
We
thank
Jean
Boiron
for
his
advice
and
encouragement.
I
Shipley
M,
Berry
H,
Brostcr
G,
Jeilkinis
M,
Closer
A,
Williams
1.
Conitrolled
trial
ott
homoeopathic
treatment
of
osteoarthritis.
Lancet
1983;i:97-8.
2
Gibsott
RU,
Gibson
SLMNI,
MacNeill
DA,
Watson-Buchanan
W.
Homoeopathic
therapy
in
rhettmatoid
arthritis:
evalitation
by
double-blind
clinical
trial.
Br]
Clin
Phtarmacol
1980;9:453-9.
3
Yttnus
M,
Alasi
AT,
Calabro
JJ,
et
al.
IPrimary
fibromyalgia
(fibrositis):
clinical
study
of
50
paticnts
with
matched
normal
controls.
Semin
Arthritis
Rthe2m
1981;11:151-71.
4
Yunus
MB.
Fibromyalgia
syndrome:
new
research
on
an
old
condition.
Br
Medj
1989;289:474-5.
S
Wolfe
F,
Hawley
DJ,
Cathey
MA,
et
a/.
Fibrositis:
symptom
frequency
and
criteria
for
diagnosis.]7
Rheumatol
1985;12:1159-68.
(Accepted
28
A-pril
1989)
Department
of
Medicine,
General
Hospital
Linz,
A
4020,
Austria
G
Biesenbach,
MD,
registrar
in
nephrology
J
Zazgornik,
MD,
professor
of
medicine
Correspondence
to:
Dr
Biesenbach.
BrMedj
1989;299:366-7
Incidence
of
transient
nephrotic
syndrome
during
pregnancy
in
diabetic
women
with
and
without
pre-existing
microalbuminuria
G
Biesenbach,
J
Zazgornik
Considerably
different
changes
in
renal
protein
excre-
tion
have
been
reported
in
diabetic
women
during
pregnancy.'
2
In
pregnant
diabetics
with
pre-existing
macroproteinuria
(¢0
5
g
protein
in
24
hour
urine
samples)
there
is
often
a
clear
increase
in
the
protein-
uria,
often
resulting
in
development
of
the
transient
nephrotic
syndrome.34
In
diabetic
women
with
albu-
min
excretion
<30
mg/day
(normoalbuminuria)
or
30-250
mg/day
(microalbuminuria)
before
pregnancy,
however,
the
syndrome
is
rarely
observed
during
pregnancy.
We
determined
to
what
extent
micro-
albuminuria
(incipient
diabetic
nephropathy)
affects
the
alterations
of
renal
protein
excretion
and
the
variables
of
kidney
function
during
and
after
preg-
nancy
and
the
incidence
of
the
syndrome
during
pregnancy
in
these
women.
Patients,
methods,
and
results
We
investigated
seven
pregnant
women
with
type
I
diabetes
and
pre-existing
normoalbuminuria
(mean
(SD)
age
22
(5)
years,
mean
(SD)
duration
of
diabetes
10
(4)
years)
and
seven
pregnant
type
I
diabetics
with
pre-existing
microalbuminuria
(mean
(SD)
age
23
(5)
years,
mean
(SD)
duration
of
diabetes
11
(3)
years).
All
women
delivered
between
36
and
40
weeks'
gestation.
Before
one
woman
became
pregnant,
during
weeks
12,
24,
28, 32,
and
36-40
of
pregnancy,
and
in
weeks
4,
12,
and
24
after
delivery
we
measured
serum
creatinine
concentration
(autoanalyser),
creatinine
clearance,
glycated
haemoglobin
concentration
(Biorad),
blood
pressure
(Riva
Rocci),
albumin
concentration
(immunodiffusion),
and
total
protein
concentration
(Biuret
method)
in
24
hour
urine
samples.
In
the
seven
diabetic
women
with
pre-existing
normoalbuminuria
there
was
a
5
9-fold
increase
in
albumin
and
a
5-7-fold
increase
in
total
protein
excretion
in
urine
during
pregnancy.
In
the
seven
diabetic
women
with
microalbuminuria
we
found
a
5
9-fold
increase
in
albumin
excretion
and
a
10
0-fold
increase
in
total
protein
excretion.
After
delivery
the
protein
excretion
fell
to
the
values
before
pregnancy
in
all
patients.
The
difference
between
the
absolute
increase
of
proteinuria
in
the
two
groups
was
signifi-
cant
(p<0005,
unpaired
t
test).
Blood
pressure
and
metabolic
control
did
not
differ
significantly
during
pregnancy
in
both
groups
(table),
and
the
variables
of
renal
function
did
not
differ
between
normo-
albuminuric
and
microalbuminuric
women.
The
transient
nephrotic
syndrome
with
protein
excretion
>3
g
in
24
hour
samples
of
urine
(3
178
g,
4907
g,
and
4-761
g)
occurred
in
three
of
the
seven
women
with
pre-existing
microalbuminuria
but
in
none
of
the
seven
with
pre-existing
normoalbuminuria.
Comment
The
transient
nephrotic
syndrome
is
rare
in
preg-
nant
diabetics
without
pre-existing
heavy
proteinuria
and
decreased
glomerular
filtration
rate
as
well
as
in
healthy
pregnant
women.'
The
extent
to
which
albumin
excretion
before
pregnancy
influences
the
increase
in
proteinuria
and
the
alterations
of
the
kidney
function
during
pregnancy
has
not,
to
our
knowledge,
been
previously
investigated
in
diabetic
women.
In
our
patients
with
normoalbuminuria
the
increase
in
proteinuria
during
pregnancy
remained
within
the
physiological
range
seen
in
healthy
pregnant
women.4'
In
the
diabetic
women
with
pre-existing
microalbuminuria
the
increase
in
proteinuria
during
pregnancy
was
significantly
higher.
Obviously
the
glomerular
basement
membrane
develops
a
greater
permeability
for
protein
during
pregnancy
in
diabetic
women
with
pre-existing
microalbuminuria
in
com-
Urtnary
protein
excretion
and
renal
function
before,
during,
and
after
pregnancy.
Values
are
means
(SD)
Diabetics
with
normoalbuminuria
Diabetics
with
microalbuminuria
Before
Third
trimester
24
Weeks
Before
Third
trimester
24
Weeks
pregnancy
of
pregnancy
after
deliverv
pregnancy
of
pregnancy
after
deliverv
Albumin
in
urine
(mg/day)
12
(3)
71('34)
13
(4)
80
(45)
478
(247)
114
(74)
Total
protein
in
urine
(g/day)
0-073
(0-056)
0
417
(0
142)
0
096
(0-073)
0
233
(0-186)
2
353
(1
211)
0-239
(0-107)
Serum
creatinine
(,tmol/l)
79(13)
68(10)
85
(7)
71(15)
63(9)
79(13)
Creatinineclearance(mlUs)
1
72
(0
18)
2-07
(0-118)
1
72
(0
17)
1
83
(0-22)
2-12
(0
40)
1
80(0
28)
Blood
pressure
(mm
Hg)
120
(9)/79
(5)
121
(7)l77
(5)
118
(7)/79
(6)
118
(8)/80
(7)
118
(6)/79
(6)
117
(6)/78
(5)
Glycatedhaemoglobin(%)
6-2(1-1)
4-7(0
8)
6-2(0
6)
6-8(0
6)
5-4(0
5)
6-8(0
5)
366
BMJ
VOLUME
299
5
AUGUST
1989
... Le groupe du NHMRC avait analysé 4 essais cliniques contrôlés, 3 contre placebo et un comparant l'homéopathie à l'ensemble des autres traitements utilisés dans la fibromyalgie. Dans les deux études de meilleure qualité [60,61], le nombre de points douloureux est diminué par rapport au placebo. Dans l'étude de Bell [60], les scores de fibromyalgie et de santé globale sont significativement améliorés. ...
... Dans l'étude de Bell [60], les scores de fibromyalgie et de santé globale sont significativement améliorés. Dans l'étude de Fisher [61] utilisant la méthode de cross-over, la douleur et le sommeil sont également améliorés par le médicament choisi après individualisation, Rhus Toxicodendron, ceci par rapport au placebo. Sur l'ensemble de ces résultats et des analyses, le NHMRC ne retient pas d'indication de l'homéopathie dans la fibromyalgie. ...
Article
Résumé La récente évaluation de l’efficacité des médicaments homéopathiques par la Haute Autorité de Santé (HAS) a été essentiellement centrée sur le médicament alors que l’homéopathie constitue une thérapeutique qu’il est nécessaire d’évaluer dans son ensemble. Après avoir décrit les caractéristiques essentielles de cette thérapeutique, l’examen des résultats obtenus dans différentes situations cliniques examinées par la HAS permet de faire des propositions d’évaluation clinique, avec des études d’observation et des essais cliniques adaptés à la singularité essentielle de la thérapeutique : l’individualisation du traitement. La poursuite de l’intégration du médicament homéopathique dans le système de santé français et de son remboursement est une condition indispensable pour assurer le développement de la recherche et la sécurité des patients.
... Moderatequality evidence from three randomised controlled trials with longitudinal data demonstrated that most improvement in pain and ROM occurs early, not late. [14] Homoeopathic medicines have been shown to provide relief and improve quality of life (QoL) in rheumatic disorders such as fibromyalgia and rheumatoid arthritis, [15][16][17] and could be a valid alternative treatment for AC. [18] Unfortunately, there is inadequate evidence to conclude the utility of individualised homoeopathic medicine (IHM) in the management of AC. ...
Article
Full-text available
Background: Adhesive capsulitis (AC) is an insidious and painful stiffening of the glenohumeral (shoulder) joint, resulting in compromised functional ability and quality of life (QoL). Objectives: Primary objective was to evaluate change in shoulder pain after individualised homoeopathy treatment for over 2 months. Secondary objective was to assess the change in the QoL and outcome related to impact on daily living (ORIDL). Methods: A single-arm, pretest-posttest, clinical study on AC was conducted on 40 participants recruited from the outpatient clinic of rheumatological disorders at Clinical Research Unit (Homoeopathy), Siliguri, West Bengal, India. Medicines were prescribed on the basis of the totality of symptoms. Changes in shoulder pain over 2 months were evaluated using the shoulder pain and disability index (SPADI). QoL was evaluated using SF-12v2 and ORIDL (participants and physician assessed), respectively. Results: Thirty-six participants completed the study and four participants dropped out. A protocol compliant sample of n = 36 was analysed. There was a statistically significant reduction of SPADI score (91.92 ± 10.22 vs. 34.14 ± 24.43; mean reduction 57.78, 95% CI 49.41–66.14, P < 0.001) and statistically significant increase in SF-12 v2 score (44.39 ± 9.70 vs. 72.27 ± 10.97; mean increase 27.87, 95% CI 23.89–31.85, P < 0.001). The Spearman’s correlation between the changes in physician assessment ORIDL scores and participants assessment ORIDL scores over 2 months suggested a statistically significant correlation (rs = 0.998, P < 0.01). Conclusion: The findings showed symptom alleviation, and improvement in the QoL after homoeopathic treatment. Randomised controlled trials are further warranted.
... Fast über 50 Jahre hat die "Rehabilitation des Eies" [2] gedauert und erst seit 2015 und der aktuellen, achten Version wird in der Ernährungsempfehlung für Amerikaner keine Obergrenze mehr genannt [3], während die deutsche Gesellschaft für Ernährung in ihren 10 Regeln das Ei überhaupt nicht aufführt. Dabei gibt es über den Ei-Konsum und die einhergehenden Effekte des Cholesterins durchaus Unsicherheiten in der Bevölkerung [4,5], womit das Update der Meta-Analyse ungeachtet der bereits großen Anzahl an Studien zum Thema helfen kann, die über Jahrzehnte verfestigten Kontroversen und Überzeugungen, ob in Wissenschaft oder Öffentlichkeit, weiter aufzulösen. ...
... Homeopathic treatment has been proven to provide relief from sign and symptoms of arthritic disorders as seen by the literature review from a large number of case reports [4][5][6][7][8][9][10]. Abundant references are available in homeopathic textbooks and repertories related to joint disorders. ...
Article
Objective: The objectives of the study were to clinically evaluate the role of Rhus toxicodendron, a homoeopathic medicine, in its various attenuations (Q, 30C, 200C, 1M) prescribed as a single medicine or with other homeopathic medicines for relieving the signs and symptoms of arthritic disorders and also to determine their useful potencies, frequency of administration and building up a new dose repetition protocol and guidelines for practice. Methods: It was a multi-centric, observational study carried out between the years 2016-2018. A total of 91 patients with arthritic disorder were selected according to the pre-defined parameters. The detailed case recording was done for each case and the patients were monitored for assessing the status of their condition according to the pre-defined criteria and the results were evaluated. Results: Out of the 91 patients, 78 patients improved in varying degrees with marked improvement seen in 34 patients, moderate in 27 patients and mild in 17 patients. No improvement was seen in 13 patients. Conclusion: Outcome of the study shows that homeopathic medicines are useful in managing arthritic disorders. However, further study with predefined laboratory and radiological investigation needs to be conducted. Other objectives of the study which included identifying the most useful potencies of Rhus toxicodendron and their frequency of administration could not be achieved. From the available results, a dose repetition observation has been provided and further study for new repetition protocol and guidelines is being formulated for conducting further trials.
... This challenge is also reported by other researchers. [19,23] Patients in the placebo group had undergone homoeopathic case history recording procedure that might contribute considerably to a possible treatment effect, decreasing the likelihood of identifying differences between the groups. [24] The biggest problem faced by clinical research in Homoeopathy is that of independent reproducibility. ...
Article
Full-text available
Background: Based on the results of Central Council for Research in Homoeopathy's previous study, wherein Sepia was indicated and prescribed in maximum number of cases, this study was planned to further validate efficacyof Sepia in the management of menopausal symptoms. Objectives: The study was conducted with the objectives of evaluating the efficacy of homoeopathic medicine – Sepia in the management of menopausal symptoms using 'The Greene Climacteric Scale' (GCS) and the quality of life using Utian Quality of Life (UQOL) scale. Materials and Methods: A randomised double-blind placebo-controlled clinical study was conducted from April 2012 to September 2014 at four research centres of Central Council for Research in Homoeopathy. Perimenopausal cases were screened (n = 471), and those fulfilling the eligibility criteria (n = 88) were enrolled and randomised to receive either homoeopathic intervention, i.e., Sepia (n = 44) or identical placebo (n = 44) and followed up for 6 months to assess them on predefined clinical parameters. The primary outcome was the change in the menopausal complaints assessed using GCS and the secondary outcome measure was change in UQOL scale. Results: Eighty-eight patients were considered for primary outcome analysis. The primary outcome measure, i.e., total score of GCS, when compared after 6 months, was reduced from 30.23 ± 8.1 to 7.86 ± 4.6 in Sepia group (improvement of 73.9%) and from 30.05 ± 8.9 to 12.73 ± 8.3 in placebo group (improvement of 57.63%) (P = 0.001). There was a statistically significant difference between both the groups, when compared after 6 months (P = 0.001). With respect to secondary outcome, the total UQOL score was 59.09 ± 7.74 for Sepia group and 57.39 ± 7.80 for placebo group at baseline, and 62.43±7.71 for Sepia group and 63.48±7.53 for placebo group after treatment indicating slight difference in quality of life after 6 months. Conclusion: Sepia is able to allay the menopausal symptoms when prescribed on symptomatic indications as per homoeopathic principles.
... In Bell's study [60], fibromyalgia scores and overall health scores are significantly improved. In Fisher's study [61] using the cross-over method, pain and sleep were also improved by the drug chosen after individualisation, Rhus Toxicodendron, and this compared to placebo. On all of these results and analyses, the NHMRC does not retain an indication for homeopathy in fibromyalgia. ...
Article
The recent evaluation of the efficacy of homeopathic medicines by the French High Authority for Health (HAS) mainly focused on the medicine, yet homeopathy is a therapy which should be evaluated as a whole. After having described the main characteristics of this therapy, the examination of the results obtained in different clinical situations examined by the HAS enables clinical evaluation proposals to be put forward, with observational studies and clinical trials adapted to the therapy's key singularity: the individualisation of the treatment. The continued integration of homeopathic medicine in the French health system and its reimbursement is an essential condition for ensuring the development of research and patient safety.
... In the present study, double-blind, placebo-controlled methodology was adapted, which is the gold standard in conventional medicine for clinical trials, but it seems that, this methodology may not be suitable for Homoeopathy practice, which is reflected in other homoeopathic studies. [18,19] This observation has been in consonance with a study where the impact of study quality on outcome in placebo-controlled trials of Homoeopathy was assessed, and it was found that studies with better methodological quality tended to yield less positive results. [20] In the present study, significant reduction in flank pain and pain during micturition was found between the groups at different time points. ...
Article
Full-text available
Background: Urolithiasis is the most common disease of urinary tract found worldwide. There are several approaches for the treatment of urolithiasis that include the use of various synthetic and natural drugs and/or surgery in the conventional system of medicine. Objective: This study was taken up to evaluate the efficacy of Lycopodium clavatum in the management of urolithiasis. Materials and Methods: A multicentric, randomised, double-blind, placebo-controlled trial was conducted. Patients having symptomatology like Lycopodium clavatum were enrolled after screening and repertorisation as per the inclusion and exclusion criteria. During acute renal colic, despite group allocation, the patients were either prescribed the indicated homoeopathic medicines or conventional medicine. The analysis was carried out with an intention-to-treat approach, and missing values were handled using Last Observation Carry Forward method. Results: There was no statistical significance between the groups (P = 0.31) in reference to the number of cases in which stones expelled during the trial. The mean size of single stone expelled was 9.4 ± 4.9 and 13.9 ± 2.2 in Verum and Placebo groups, respectively (P = 0.12). There was also no significant difference in the mean size of mean size of multiple stones; in Verum group (10.1 ± 5.3) and Placebo group (16.1 ± 9.1) (P = 0.11). For assessment of pain and dysuria, Visual Analogue Scale was used, and a statistically significant difference was found between the groups (P = 0.039) for pain, and positive trend for Homoeopathy was noted for dysuria. A verified symptom syndrome of Lycopodium clavatum has been observed. Conclusion: Future studies with pragmatic study design and individualistic Homoeopathy can be undertaken to assess the effectiveness of treatment in urolithiasis.
Article
Background: Prognostic factor research methodology has not yet been applied to randomized clinical trial data of homeopathic medicines. Objectives: To investigate the principle of individualization in homeopathy by developing a prognostic factor prediction model. Method: A pooled, in-dividual patient data meta-analysis of 3 randomized trials -investigating the efficacy of a homeopathic gel (Spiroflor SRL®) containing Rhus toxicodendron as a key ingredient in osteoarthritis of the knee and acute low back pain. The prognostic value of a predefined set of 5 typical R. toxicodendron symptoms was investigated by assessing treatment-by-symptom interactions on pain as an outcome measure in a regression model. Results: The pooled dataset consisted of 284 patients in the Spiroflor SRL group and 275 patients in the control group. Adjusted for pain at baseline, a statistically significant effect modification for the symptoms "numbness or tingling of the affected part" (+2.0 mm VAS; p = 0.02), "amelioration by movement" (-5.6 mm VAS; p = 0.01), and "amelioration of pain by local heat" (+7.0 mm VAS; p = 0.02) was found. Conclusions: Investigating aspects of treatment individualization in homeopathy using randomized trial data and standard meta-analytical techniques is possible. The symptom amelioration by local heat is of possible value as a homeopathic symptom (prognostic factor) predicting an increased likelihood of pain relief following treatment with the homeopathic product.
Article
Full-text available
This short treatise addresses a philosophical question concerning the place of homeopathy in our modern world. The question raised is whether a therapeutic system as peaceful, mild, and non-violent as homeopathy can survive and grow within a society that often displays the opposite characteristics. Much of contemporary society is more interested in fast and impressive cures, even if these may also bring side effects; whereas homeopathy can offer solutions with a personalized approach that requires long hours of case study by the homeopath to find the correct personal remedy that aims to bring about positive results, which the therapy can produce in deep chronic diseases. The conclusion drawn is that homeopathy does not readily fit within a modern and violent society that prefers quick and invasive solutions to its clinical problems.
Article
Full-text available
The effectiveness of percutaneous ethanol injection therapy was investigated in 30 patients who had hepatocellular carcinoma (18 had a single lesion and 12 had multiple lesions). In patients who had a single lesion, ethanol injection was especially effective. Histopathologic examination, performed in nine cases in this group, showed that the tumor was completely necrotic in six cases, 90% necrotic in two cases, and 70% necrotic in the remaining case. In eight other cases with a single tumor, follow-up angiography showed complete disappearance of the tumor stain. In the other case, CT showed the nonenhanced low-density area. In the 12 patients with multiple lesions, ethanol injection was performed as part of an integrated treatment plan. Eleven were still alive at the end of the study (the mean follow-up period was 5.8 months). We conclude that ethanol injection may be a valuable treatment for hepatocellular carcinoma.
Article
We administered a 17-item symptom questionnaire modified from Campbell to 155 patients with fibrositis diagnosed at 3 centers, each using different criteria sets. A high degree of agreement in symptom proportions was found among centers. "Fibrositic" symptoms were also common in 136 patients with a variety of rheumatic diseases but not in the 58 normal individuals studied. Symptoms distinguished fibrositis patients from normals easily, but had insufficient specificity to distinguish them from other rheumatic disease patients. The tender point count better separated fibrositic and nonfibrositic patients than historical criteria. No combination of questions and tender point count performed better than the tender point count alone.
Article
In a double-blind, placebo-controlled crossover study to compare the homoeopathic remedy Rhus tox. 6X with fenoprofen in osteoarthritis of the hip and knee, fenoprofen was shown to have beneficial analgesic and anti-inflammatory effects which differed significantly from those of placebo. The effects of Rhus tox. 6X and placebo did not differ significantly. Patient preference was for fenoprofen. Side-effects were not severe but were seen more frequently with fenoprofen. Similar results were seen in all patients regardless of whether they had been referred to and assessed by a homoeopathic physician or a rheumatologist.
Article
Lasers provide a means of delivering high intensity light to small well-defined areas under precise control. The biological response depends on the light wavelength and intensity and the absorption characteristics of the target organ. The most important effects are thermal and include tissue vaporization, necrosis with later sloughing, and necrosis stimulating an inflammatory response which may lead to local fibrosis. The Carbon Dioxide Laser can cut or vaporize neoplastic tissue in areas accessible to rigid endoscopy, but the more penetrating Nd YAG and Argon laser beams can be transmitted via flexible fibers and have greater potential for destroying larger tumors without unacceptable damage to surrounding areas. More selective tumor phototherapy is possible in some organs by sensitization with HpD (hematoporphyrin derivative) and subsequent treatment with a dye laser. This effect is non-thermal and depends on the production of singlet oxygen by activated HpD. The precision possible for local treatment of solid tumors with lasers is greater than for almost any other techniques, but careful quantitative studies are needed to establish the appropriate treatment parameters in any particular situation.
Article
Detailed clinical study of 50 patients with primary fibromyalgia and 50 normal matched controls has shown a characteristic syndrome. Primary fibromyalgia patients are usually females, aged 25-40 yr, who complain of diffuse musculoskeletal aches, pains or stiffness associated with tiredness, anxiety, poor sleep, headaches, irritable bowel syndrome, subjective swelling in the articular and periarticular areas and numbness. Physical examination is characterized by presence of multiple tender points at specific sites and absence of joint swelling. Symptoms are influenced by weather and activities, as well as by time of day(worse in the morning and the evening). In contrast, symptoms of psychogenic rheumatism patients have little fluctuation, if any, and are modulated by emotional rather than physical factors. In psychogenic rheumatism, there is diffuse tenderness rather than tender points at specific sites. Laboratory tests and roentgenologic findings in primary fibromyalgia are normal or negative. Primary fibromyalgia should be suspected by the presence of its own characteristic features, and not diagnosed just by the absence of other recognizable conditions. This study has also shown that primary fibromyalgia is a poorly recognized condition. Patients were usually seen by many physicians who failed to provide a definite diagnosis despite frequent unnecessary investigations. A guideline for diagnosis of primary fibromyalgia, based upon our observations, is suggested. Management is usually gratifying in these frustrated patients. The most important aspects are a definite diagnosis, explanation of the various possible mechanisms responsible for the symptoms, and reassurance regarding the benign nature of this condition. A combination of reassurance, nonsteroidal antiinflammatory drugs, good sleep, local tender point injections, and various modes of physical therapy is successful in most cases.
Article
Twenty-three patients with rheumatoid arthritis on orthodox first-line anti-inflammatory treatment plus homeopathy were compared wtih a similar group of twenty-three patients on orthodox first-line treatment plus an inert preparation. There was a significant improvement in subjective pain, articular index, stiffness and grip strength in those patients receiving homoeopathic remedies whereas there was no significant change in the patients who received placebo. Two physicians were involved in prescribing for the patients and there were no significant differences in the results which they obtained. No side effects were observed with the homoeopathic remedies.
US-guidcd pcrCutatlcous alcohol iIjectioIn of small hepatic aind abdomiial tuimiors
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Livraghi T, Fcsti Ml, Monti F, Salmi A, Vcttori C. US-guidcd pcrCutatlcous alcohol iIjectioIn of small hepatic aind abdomiial tuimiors. Radiology 1986;161 :3(9-12.
G Intcrstitial lascr hypcrthermia-stttdics in the nortmal liver
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Stcger AC, Bown SG, Clarke C(G Intcrstitial lascr hypcrthermia-stttdics in the nortmal liver. fBrj Surg 1988;75:59X