Pathophysiology and pathogenesis of generalized peritonitis
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907. Problems in veterinary medicine
Peritonitis is a complex disease state that results in many pathophysiologic alterations that affect multiple organs. The clinician must possess a thorough understanding of the pathophysiology and pathogenesis of the disease so that effective treatment can be instituted. Treatment should be directed at eliminating the cause of peritonitis and preventing or reversing the resulting pathophysiologic alterations.
Available from: Mohamed El-Boshy
- "Severe congestion and necrotic lesions were additionally observed in the small colon. Discussion In horses, peritonitis is considered a potentially fatal condition due to the involvement of multiple vital organs (Ricketts 1987; Hosgood and Salisbury 1989). In the present study, 36 draft horses were affected by peritonitis as revealed by the analysis of the peritoneal fluid. "
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ABSTRACT: To our knowledge, this is the first report describing the oxidant–antioxidant status in horses clinically affected with peritonitis. The present study was carried out to investigate the importance of oxidative stress markers and antioxidant parameters in the prediction of clinical outcomes of peritonitis in draft horses. Thirty-six draft horses were used in this study in the period between March 2006 and March 2009. Diagnosis of the clinical cases was based on the physical examination, clinical pathology, and necropsy. Our results showed that there was a significant increase (p < 0.05) in the level of malondialdehyde (MDA) of nonsurvivors in comparison with that of survivors. There was, however, a significant decrease (p < 0.05) in the activity of superoxide dismutase, catalase, reduced glutathione, vitamin C, and nitric oxide (NO). Analysis of receiver operating characteristic indicated a high sensitivity (90%) and specificity (86.71%) of MDA level (p < 0.001) to predict the outcome of peritonitis. Results of peritoneal fluid analysis revealed an abnormal physical appearance with a significant increase (p < 0.05) in total leukocytic counts and total protein levels. In conclusion, our findings might indicate that lipid peroxide levels and antioxidant parameters could have a prognostic significance in draft horses showing peritonitis.
Available from: doiserbia.nb.rs
- "A normal small quantity of peritoneal fluid in the abdomen of an adult cow does not mean that the carrying out of abdominocentesis has no diagnostic value. Peritoneal fluid changes quantitatively as well as qualitatively, especially in more serious diseases of abdominal organs (Hirsch and Townsend, 1982; Hosgood and Salisbury, 1989; Oehme and Moorsdy, 1970). There is also extensive description of normal bovine peritoneal fluid (Anderson et al., 1995; Radostits et al., 2007). "
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