Aberrant T cell-mediated immunity in untreated schizophrenic patients: Deficient interleukin-2 production

ArticleinAmerican Journal of Psychiatry 146(5):609-16 · June 1989with4 Reads
Impact Factor: 12.30 · DOI: 10.1176/ajp.146.5.609 · Source: PubMed


    The authors examined the immune status at the cellular and humoral levels of 16 untreated schizophrenic patients. No abnormality in the distribution of T cell subsets (CD4+, CD8+) was detected. The proliferative response to the T cell mitogen phytohemagglutinin was normal. No increase in the number of T cells showing activation markers, such as human leukocyte antigens and interleukin-2 receptors, was noted. Conversely, function studies revealed a clear deficiency in interleukin-2 production by purified T cells. This lower production was probably intrinsic to the patients' T cells, since interleukin-2 production showed normal sensitivity to prostaglandin E2-mediated down-regulation by autologous monocytes.