Bilateral eyelid swelling attributable to lymphosarcoma in a horse

Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616.
Journal of the American Veterinary Medical Association (Impact Factor: 1.56). 05/1989; 194(7):939-42.
Source: PubMed


Bilateral swelling of upper and lower eyelids was caused by lymphocytic infiltration in an 8-year-old Thoroughbred mare. The condition worsened with pregnancy and became associated with subcutaneous dissemination of lymphosarcoma at distant sites.

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    • "Involvement of the central nervous system results in a variety of neurological signs, depending on the lesion's location; these signs may include ataxia, cranial nerve deficits, Horner's syndrome, urinary and/or faecal incontinence or seizures (Neufeld 1973; van den Hoven and Franken 1983; Shamis et al. 1984; Kannegieter and Alley 1987; Zeman et al. 1989; Lester et al. 1992; Morrison et al. 2008; Munoz et al. 2009). Ocular manifestations associated with multicentric lymphoma include intermittent eyelid swelling that may shift from one eye to the other, chronic ocular discharge, oedematous third eyelid, unilateral exophthalmos, corneoscleral masses and chronic uveitis that is unresponsive to treatment (Murphy et al. 1989; Rebhun and Del Piero 1998; Stoppini et al. 2005; Germann et al. 2008). Syndromes such as pseudohyperparathyroidism paraneoplastic pruritis and alopecia also have been reported in horses with multicentric lymphoma (Marr et al. 1989; Finley et al. 1998). "
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    ABSTRACT: Lymphoma, although rare, is the most common haematopoietic neoplasm encountered in horses and can occur at any age, with horses 4–10 years more commonly affected. Lymphoma can be classified into multicentric, alimentary, mediastinal, cutaneous and solitary. Clinical signs are typically nonspecific until the disease has progressed to end-stage at which time clinical signs reflect function of organ(s) involved. Horses with the cutaneous form of lymphoma typically present with multifocal skin lesions and no other clinical signs. Like the nonspecific clinical signs of lymphoma, results of complete blood count (CBC) and serum biochemistries are not often helpful with diagnosis, but lymphoma should be considered if anaemia, hyperfibrinogenaemia, hyperproteinaemia and hypoalbuminaemia are observed without a clear indication of infectious disease. Identification of neoplastic lymphocytes during cytological examination of a body cavity effusion can confirm the presence of lymphoma. Typically, ante mortem confirmation of lymphoma is made through histopathological examination of a biopsy or cytological examination of a fine needle aspirate of a suspected lesion. Observation of compression or destruction of normal tissue architecture by invading neoplastic cells during histological examination is indicative of lymphoma. Additional diagnostics that may improve our knowledge of equine lymphoma include detection of hormone receptors, immunophenotyping, and immunohistochemical analysis for tumour proliferation rates. Prognosis of horses with lymphoma depends on the form of lymphoma and stage at which the horse is presented but death is the common outcome of this disease. Current treatment options are surgical excision, radiation or administration of chemotherapeutic drugs. Treatment of horses with lymphoma can result in palliation and occasional resolution of this disease. Equine oncology is in its infancy, but through further documentation of horses with lymphoma and their response to therapy, a clearer understanding of the disease process and effective treatment of this neoplasm can be developed.
    Preview · Article · Mar 2011
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    ABSTRACT: Clinical, ultrasonographic and pathological findings of a cutaneous, multilocular T-cell lymphosarcoma (malignant lymphoma) in a 13-year-old, brown Austrian warmblood mare are reported. The horse was under clinical observation, and the tumours were sonographically monitored over an 8 month period, revealing worsening of body condition, weight loss, lameness of the left hindlimb and a slight increase in the tumours size. Most of the tumours were covered by normal skin, one showed ulceration. Ultrasonography of the tumours allowed accurate anatomical localization in relation to the adjoining tissue, assessment of their internal structure, of involvement of adjacent muscles and of a regional lymph node, and it facilitated the percutaneous fine-needle aspiration. Necropsy confirmed muscular infiltration in three locations. Light microscopy and immunohistology led to the diagnosis of a T-cell lymphosarcoma.
    No preview · Article · Mar 1998 · Zentralblatt für Veterinärmedizin. Reihe A
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    ABSTRACT: A periocular nodular sarcoid of the right upper and lower eyelids was diagnosed in an 11-year-old Thoroughbred mare. Computed tomography scan revealed the extent of the tumor. The mass was surgically debulked under general anesthesia, and the affected periocular region was injected intralesionally with Bacillus of Calmette and Guerin (BCG). An emulsion of cell wall fractions was used, which has been modified to reduce the toxic and allergic effect, but retain the antitumor activity. In total, five injections were performed at 2-week intervals. At follow-up 7 months after the last BCG injection, the tumor was completely resolved. Two years after the last treatment, the horse remains tumor-free.
    No preview · Article · May 2004 · Veterinary Ophthalmology
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