This article has no abstract; the first 100 words appear below.
HUMAN Central-nervous-system infection with Herpesvirus hominis (herpes-simplex virus), first described in 1941,¹ is by no means rare. A number of reports describe the clinical, pathological and epidemiological aspects of encephalitis caused by this virus and its frequency in nonbacterial Central-nervous-system infections.²³⁴⁵ Because of its sporadic occurrence and difficulties in establishing diagnoses during life, knowledge of the disease has been based upon histologic study. However, accurate and rapid diagnosis during life is required if treatment with 5-iodo 2′-deoxyuridine (IUDR) is contemplated. This report reviews 49 patients with Central-nervous-system disease associated with herpes-simplex virus studied in this laboratory in the past twenty-five . . .
*From the Department of Virus Diseases, Walter Reed Army Institute of Research (requests for reprints should be addressed to Colonel Edward L. Buescher, M.C., USA, at the Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, D. C., 20012).
Presented in part before the annual meeting of the American College of Physicians, New York City, April 18, 1966.
We are indebted to Drs. Charles Adair, Clifton Arrington, Joseph A. Bellanti, Robert E. Blount, Jr., Francis C. Cadigan, Jr., Irving Crawford, Harry E. Dascomb, Richard T. Johnson, Bernard Portnoy, Aaron F. Rasmussen and Howard A. Weinberger, who at various times supervised the Diagnostic Section of the Department of Virus Diseases, thus leading to the accumulation of cases analyzed here, and Clarence L. Parker and Oliver Dandridge for technical assistance.
† Formerly, virologist, Department of Virus Diseases, Walter Reed Army Institute of Research (present address, Department of Virology, SEATO Medical Research Laboratory, APO San Francisco 96346).
‡ Chief, Department of Virus Diseases, Walter Reed Army Institute of Research; clinical associate professor of pediatrics, Georgetown University School of Medicine.
§ Chief, Department of Bacteriology, Walter Reed Army Institute of Research; clinical associate professor of medicine, George Washington University School of Medicine.
¶ Formerly, virologist, Department of Virus Diseases, Walter Reed Army Institute of Research (present address, Division of Biological Standards, National Institutes of Health, Bethesda, Maryland).