The Functioning and Well-being of Depressed Patients: Results From the Medical Outcomes Study

Department of Psychiatry and Biobehavioural Sciences, University of California, Los Angeles, Los Ángeles, California, United States
JAMA The Journal of the American Medical Association (Impact Factor: 35.29). 09/1989; 262(7):914-9. DOI: 10.1001/jama.1989.03430070062031
Source: PubMed


We describe the functioning and well-being of patients with depression, relative to patients with chronic medical conditions or no chronic conditions. Data are from 11,242 outpatients in three health care provision systems in three US sites. Patients with either current depressive disorder or depressive symptoms in the absence of disorder tended to have worse physical, social, and role functioning, worse perceived current health, and greater bodily pain than did patients with no chronic conditions. The poor functioning uniquely associated with depressive symptoms, with or without depressive disorder, was comparable with or worse than that uniquely associated with eight major chronic medical conditions. For example, the unique association of days in bed with depressive symptoms was significantly greater than the comparable association with hypertension, diabetes, and arthritis. Depression and chronic medical conditions had unique and additive effects on patient functioning.

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    • "3 Social well-being: The quality of interactions with others (Ryff and Singer, 1998). This overview indicates that well-being could be approached through its objective components, but it is also emphasized by the subjective assessment of both quality of life and health (Wells et al., 1989). For Diener et al. (1998), SWB is a person's evaluation of his/her life that involves between three and six dimensions. "
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    • "It is considered to be the major cause of years lived with disability (YLD) and by 2020 is expected to be among the two main causes of disability adjusted years (DALYs) together with ischemic heart disease [4]. The functional limitations caused by depression are equal to or even sometimes greater than the ones engendered by many other chronic medical conditions [5]. In spite of the great advances achieved in treatment of depression during the last decades, between 20 and 30% of cases are not adequately solved by first agent treatments (also known as treatment-resistant depression in literature) [6]. "
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