Platelet activation and secretion with emotional stress

ArticleinCirculation 71(6):1129-34 · July 1985with3 Reads
DOI: 10.1161/01.CIR.71.6.1129 · Source: PubMed
Abstract
Platelets are believed to play a role in the pathogenesis of atherosclerosis and of the vascular obstruction that causes the acute complications of coronary artery disease. Since specific behavioral patterns appear to be related to the development of coronary artery disease and since emotional stress may predispose an individual to acute cardiovascular ischemia, it was hypothesized that platelet activation by catecholamines might be involved in these events. To study emotional stress, plasma samples were obtained from 61 senior medical residents immediately before they were to speak in public. There were significant increases in the plasma concentrations of the platelet-secreted proteins platelet factor 4 and beta-thromboglobulin and epinephrine and norepinephrine immediately before speaking, which demonstrates that platelet activation and secretion occur in association with this type of emotional stress. Four trials were carried out to study the mechanism for this observed platelet secretion: (1) phenoxybenzamine, (2) propranolol, (3) 650 mg aspirin, and (4) 80 mg aspirin were given several hours before the public speaking engagement. Neither phenoxybenzamine nor propranolol in doses that blocked the hemodynamic effects of alpha 1- and beta 1-adrenergic stimulation modified platelet secretion. Aspirin also did not block platelet secretion, which suggests that platelets were not being stimulated through a cyclooxygenase-dependent pathway. This study provides direct evidence of platelet secretion in vivo in association with emotional stress, and underscores the potential importance of platelet activation and secretion in the acute events that occur in patients with vascular disease.
    • "One of the studies showed an effect on platelet aggregation following 12 weeks of either escitalopram (SSRI) or nortriptyline (NRI), but the finding was confined to mood responders [33]. Another important factor to consider in interpreting the reported findings is that acute life stressors can physiologically elicit activation of circulating platelets [30,31]. Some studies have shown that platelet responses to acute life stressors are more exaggerated in depressed patients relative to healthy subjects [31,35]. "
    Article · Jan 2015 · Annals of Behavioral Medicine
    • "Downloaded by [ The platelet counts observed in our study were higher in lambs from the H group. From a welfare point of view, it is difficult to explain the increase in platelets in the less-stressed lambs. Some studies indicate that platelets increase in humans when they feel emotionally stressed (Levine et al., 1985). However, Wallen (1997) concluded that platelet secretion seems to invariably increase with physical exercise, suggesting that responses of platelets to mental stress are highly variable between individuals and situations. "
    [Show abstract] [Hide abstract] ABSTRACT: Postweaning management strategies that include an element of social enrichment may reduce weaning stress and improve welfare and productive performance. We analyzed the effect of postweaning handling strategies on welfare and production traits in lambs. After weaning, 36 lambs were assigned to 3 experimental groups with 12 lambs each (control [C], fattening with gentle human female contact [H], and fattening with 2 adult ewes [E]). The average daily gain (ADG) was estimated. Blood samples were taken, and infrared thermography was used to estimate stress variables. There were significant differences among treatments (in favor of alternative strategies) regarding production and stress variables (cortisol, glucose, and creatine kinase). The results suggest that the lambs handled gently during the fattening were less reactive and better able to modulate their physiological stress. The E group adapted better to acute stress than the C group but was less efficient in modulating chronic stress. Both treatments showed higher slaughter live weights and better ADGs compared with the control. The use of social enrichment at weaning, especially to establish a positive human-nonhuman animal bond, alleviates lamb weaning stress and improves welfare and performance.
    Full-text · Article · Aug 2014
    • "Platelet aggregability appears to increase immediately after acute psychological stress113114115116 . Additionally , many studies report increases in the levels of the platelet activation markers circulating platelet factor 4 (PF4) and beta-thromboglobulin (BTG) among healthy individuals [6,116117118119120121 and among individuals with essential hypertension [122] and with angina pectoris [123]. However, not all studies have reported significant changes in platelet aggregability124125126 and platelet activation markers [123, 127, 128] in response to acute stress. "
    [Show abstract] [Hide abstract] ABSTRACT: Acute psychological stress can produce significant hemoconcentration as well as prothrombotic changes in blood, both of which may have potentially harmful effects on the cardiovascular system. It is unclear whether these effects are independent or have influence on each other. This review discusses research investigating the effects of acute psychological stress on hemoconcentration and hemostasis and explores future directions for psychohematology research. Physiology, associations with cardiovascular disease, and relationships between acute psychological stress are discussed independently for hemoconcentration and hemostasis, followed by an examination of the effects of stress-hemoconcentration on hemostasis. Traditional methods of adjusting for stress-hemoconcentration effects (e.g., calculated plasma volume or hematocrit level corrections) may not be appropriate when examining stress-induced changes in hemostasis. The effects of acute stress on hemostasis should be examined in conjunction with hemoconcentration.
    Full-text · Article · May 2011
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