Increased frequency of complete hydatidiform mole in women with repeated abortion

ArticleinGynecologic Oncology 31(2):310-4 · November 1988with4 Reads
DOI: 10.1016/S0090-8258(88)80009-X · Source: PubMed
Abstract
The association between spontaneous abortion and gestational trophoblastic disease (GTD) has been investigated in a study based on 93 women with 2 consecutive (repeated) spontaneous abortions and 82 control subjects who delivered normal babies. Nine molar pregnancies were observed among 7 of the 93 cases of repeated abortion while no control reported previous GTD. This difference was statistically significant and was not explained by allowance for age and number of pregnancies between cases and controls (chi 2(1) = 4.20; P = 0.04). When the observed number (9) of hydatidiform mole in the 385 pregnancies of the women with repeated abortion was compared with the expected one (0.28) based on the regional frequency data, the estimated relative risk was 32.1 with a 95% confidence interval from 13.9 to 63.3. The present findings confirm the association between GTD and spontaneous abortion and indicate that the risk is larger in women with repeated abortions.
    • "Murdoch et al. [10] pointed out that NLRP7, in addition to causing RHMs, may also be responsible for causing recurrent abortions, stillbirths and intrauterine growth retardation. Additionally, epidemiological studies have shown that the frequency of moles is higher in patients with recurrent SAs than in women from the general population [8,25]. Furthermore, women with recurrent moles may have CHMs, PHMs and SAs, indicating that these three histopathological entities have, at least in some cases, the same underlying etiology and are a continuous spectrum of the same condition [24]. "
    Dataset · Mar 2015 · Obstetrics and Gynecology
    • "Previous history of spontaneous abortions is a strong risk factor for subsequent moles and choriocarcinoma, and indicates a genetic predisposition in these patients [32,454647. Two independent studies, from the US and Italy, have shown that the incidence of HMs in women with two or more spontaneous abortions is 7 [48] and 32 [49] times higher than the incidence of moles in the general population. Recurrence of moles occurs in 0.57 to 5% of all women who have had one mole2829303132333435. "
    Full-text · Article · · Obstetrics and Gynecology
  • [Show abstract] [Hide abstract] ABSTRACT: The association between spontaneous abortion and ectopic pregnancy was evaluated in a case-control study conducted on 161 women (cases) with recurrent spontaneous abortions (two or more consecutive spontaneous abortions) and 170 control subjects who delivered normal infants. The risk of ectopic pregnancy in women with a history of recurrent spontaneous abortion was about fourfold that of controls (relative risk adjusted for age and number of pregnancies = 4.3; 95% confidence interval 1.4-14.7). This association was confirmed by comparing the observed number of extrauterine pregnancies in women with recurrent spontaneous abortions with the expected number computed from regional data on the frequency of ectopic pregnancies; the estimated relative risk was 3.7, with a 95% confidence interval of 2.2-7.0. The present report found an association between spontaneous abortions and ectopic pregnancies, suggesting some common risk/etiologic factors for these two reproductive failures.
    Article · Mar 1989
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