Psychosis associated with bupropion treatment

ArticleinAmerican Journal of Psychiatry 142(12):1459-62 · January 1986with5 Reads
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    The authors describe the development of acute psychoses in four patients treated with bupropion, a unicyclic aminoketone antidepressant. In two of the cases the psychoses seemed to be affected by dose. The mechanism responsible for the psychotic reactions is unclear, although it may involve perturbation of dopaminergic systems. On the basis of their experience, the authors offer recommendations regarding the clinical use of bupropion.