A 50-year-old patient presented with severe fatigue, fevers, unexplained weight loss, and night sweats of two-week duration. Within two days, an episode of intravascular hemolysis was noted. Relevant medical history supported a possible diagnosis of Babesia spp. Molecular testing revealed Babesia DNA although the peripheral blood smear did not demonstrate any classic parasite forms. Treatment for ... [Show full abstract] Babesia was begun and the patient improved.