Studies on the proteins of human saliva Biochim
Pooled human saliva was submitted to a chromatographic fractionation on diethylaminoethyl-cellulose, and some of the eluates were further separated by chromatography on carboxymethyl-cellulose. Two plasma proteins, albumin and γA-immunoglobulin, were identified among the salivary components, and appeared to be present in rather high concentrations. Among the saliva-specific components here identified, some were already well known from the literature, e.g. salivary amylases (EC 220.127.116.11), lysozyme (EC 18.104.22.168), salivary mucins, and a component giving a double-bowed precipitin line in immunoelectrophoresis. In addition to these, a number of components is here described for the first time: salivary α1-, α2- and β1-globulins, mucosal α2-globulin, and a cathodal component. In addition, the occurrence in saliva of lactoferrin, an iron-binding protein previously reported in milk and bronchial secretions, has been established.
- "Using a single saliva sample from a healthy, nonsmoking male subject, the researchers were able to identify 102 proteins, including 35 salivary proteins and 67 common serum proteins. Identifying all of the serum proteins present in saliva could take many more years. "
Article: Science behind human saliva[Show abstract] [Hide abstract]
ABSTRACT: Saliva is a complex fluid, which influences oral health through specific and nonspecific physical and chemical properties. The importance of saliva in our everyday activities and the medicinal properties it possesses are often taken for granted. However, when disruptions in the quality or quantity of saliva do occur in an individual, it is likely that he or she will experience detrimental effects on oral and systemic health. Often head and neck radiotherapy has serious and detrimental side effects on the oral cavity including the loss of salivary gland function and a persistent complaint of a dry mouth (xerostomia). Thus, saliva has a myriad of beneficial functions that are essential to our well-being. Although saliva has been extensively investigated as a medium, few laboratories have studied saliva in the context of its role in maintaining oral and general health.
- "The immunohistochemical data here presented give additional strength to our previous demonstration (Masson et al., 1965b) that lactoferrin is secreted by the bronchial tree. The cellular origin of this protein could be traced to the glandular acini, whereas neither the epithelial lining nor the alveolar walls appeared to take part in its production . "
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ABSTRACT: In dieser Arbeit wird auf die Vorteile der gemischten stationären Phasen hingewiesen, mit deren Hilfe man hohe Trennungsfähigkeit, besonders bei der Trennung von Gemischen verschiedenartiger Stoffe, erreichen kann. Es wird festgestellt, daß die Trennungsfähigkeit der Kolonne davon abhängt, in welcher Weise die betreffenden stationären Phasen in die Kolonne eingebracht werden. Die beste Trennwirkung wird erreicht, wenn man die gemischte stationäre Phase als homogenes Gemisch in die Kolonne einfüllt. Es wird die Arbeitsweise zur chromatographischen Trennung eines Gemisches von Butyraldehyden, Toluol und Butylalkoholen ermittelt.
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