Sixty four patients were treated with lithium orotate and observed for time periods ranging from four months to two and one half years. Lithium orotate is of truly unparalleled efficiency in the treatment of constitutional migraine, constant headache and hemicrania. Also in the treatment of depression, alcoholism and epilepsy, lithium orotate has proven very useful without any problems in the application. Lithium orotate is effective at uncommonly low dosages and causes no negative side effects. Lithium citrate and lithium carbonate are far less effective than lithium orotate. The specific principle is considered to be a directed intracellular transport of lithium by means of the orotic carrier molecule, which has a high affinity for tissue dependent on the pentose pathway, e.g., glia and the blood brain barrier. The directed carrier principle of the lithium orotate therapy makes a determination of the lithium level in blood serum unnecessary. The effectiveness of lithium therapy as such is based on a membranal and cellular displacement of sodium.