Health is considered as wealth. In present times people have become more cautious about their health. Health is conceived as positive state of physical, mental and social well-being besides the absence of disease/illness. Several personality specific constructs influence diagnosis, progression and prognosis of diseases. There are several positive personal attributes, such as emotional stability, optimism, positive affectivity, resilience and self-efficacy that affects people's attitude to their life. Emotional stability serves as the effective determinant of the personality pattern and development of stable emotional behavior throughout the development periods. Optimism is defined as an enduring tendency to expect good personal outcomes in the future. Positive Affectivity reflects the extent to which a person feels enthusiastic, active, and alert. Resilience is the ability to successfully cope with change or misfortune. Self-efficacy makes a difference in how people feel, think and act. The most significant question of the time is to provide an explanation to why some people have relatively higher proneness to certain class of illness, or whether individuals differ in their disease susceptibility. The present review is an attempt to identify the pattern of relationship between personal attributes and state of physical health and psychological well-being of people. The need of imparting life skills, such as ability for adaptive and positive behavior that enables stressed person to deal effectively with demands and challenges of everyday life style. Reviews suggest that all these personal attributes are positively related with health status. Health has always been considered valuable by people. Since ancient times the focus has been mainly on the causation of ill-health, not on well-being. However, there have been controversies regarding the etiology/causes of ill-health and people have been adopting different systems of cure. Integration of mind and body in determining one's health state has been a controversial issue of the 20 th century. During this period new advancements in the medical technology made the approaches to treatment more efficient and effective. Thus biomedical model gained more popularity due to the fact that it considered a broad view of human physiology and produce a quick and steady mode of diagnosis, cure and recovery from illness. Although, biomedical model explains illness in terms of biological causation, such as viruses, bacteria, lesions and carcinogens, the emerging trends in the field of health psychology and medical sociology conceive the health to be determined by psychological and sociological factors. Biomedical approach does not allow the opportunity to understand the disease in the context under which patient's illness occurred, such as family background, work and family stress, communities, work group, etc. with the longstanding concern of the factors other than the biological one such as psychological, social, neuro-immunological. Mind-body interaction was again started becoming the focus of attention. However, the mind-body interaction was being recognized, but not so directly; it has taken several other modified forms such as psychological, sociological and other such factors that may have determining effect on human health. With the changing scenario, role of behavioral and psychological factors could be recognized with the emerging issues, such as why some people get ill more frequently or are more prone to develop certain kind of illness than others. Freud