Clear cell carcinoma is a distinct entity from other epithelial ovarian carcinomas, not simply because of its characteristic
histology, but because of its specific biological and clinical behaviour. It is the second most common histological subtype
of ovarian cancer, after serous carcinoma, accounting for 4–12% of ovarian epithelial cancers in Western countries [1, 2].
It comprises a greater
... [Show full abstract] proportion of ovarian epithelial cancers in Japan, up to 20% [1], where the incidence is rising [3].
Even in the West, clear cell carcinoma accounts for a significantly higher proportion of ovarian cancers in people of Japanese
descent, compared to all other ethnic groups [2].