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[Experimental animal studies on the question of thalidomide and nerve damage]
Beim Vergleich der teratogenen und neurotoxischen Wirkung von Thalidomid mit dem neuen Hypnosedativum Biglumid (K-2004) ergaben sich deutliche Unterschiede. Mibildungen zeigten sich nur beim Thalidomid. Andere Befunde sprechen fr eine Entwicklungsverzgerung bei mit Thalidomid behandelten Embryonen vor allem im Spinalganglion.Comparison of the teratogenic and neurotoxic influence of thalidomide with the new hypnosedative preparation Biglumide (K-2004) revealed significant differences. Malformations could be seen only after treatment with thalidomide. Some results concerning the thalidomide-treated group of animals could be interpreted as a retardation of development in the posterior root ganglia.
An intoxication by peroral and subcutaneous application of carbon tetrachloride was produced experimentally in 40 bastard rabbits. The pathohistological findings, especially in the nn. ischiadici, are described. The fine-tissue alterations of the myelin sheaths and axons and to a lesser extent in the neurilemma and the corresponding cerebro-spinal central spheres are evaluated as toxic polyneuropathies of a transition and mixed type. Since the nerves of the injected extremity were impaired most severely by subcutaneous application, the immediate operation of the toxic substance on the tissue by diffusion, with localized disturbance of metabolism, circulation, and ionic metabolism, is regarded as probable.The comparison of the findings in the two methods of intoxication with each other and with the control group proved to be partially significant.Copyright © 1973 S. Karger AG, Basel
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