Sulindac versus ibuprofen in sprains and strains

British Journal of Sports Medicine (Impact Factor: 5.03). 04/1984; 18(1):30-3. DOI: 10.1136/bjsm.18.1.30
Source: PubMed


In a double-blind parallel group randomised study 191 patients with acute sprains and strains of ankle, hip, shoulder or knees were treated with either 400 mg sulindac or 1200 mg ibuprofen per day for 4 days; of these, 176 completed the trial. Spontaneous pain (day and night), pain on active movement, swelling and tenderness were assessed before and after the treatment period along with a physician's and patient's assessment of therapy at the end of the study. The vast majority of patients had a successful outcome whichever treatment they were taking. No patients reported any adverse effect during the study.

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    • "Wolfe et al. (2001) also claim reduction in swelling by NSAID, without comparing them to other drugs. Comparative surveys of different drugs revealed a significant reduction of ankle swelling for all NSAIDs in comparison with the day of injury and also with the use of analgesic (Hayes et al, 1984; Calligaris et al, 1993; Mcllwain & Platt, 1988; Lyrtzis et al, 2011). Quality of life evaluation was performed using SF-36 questionnaire. "
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    ABSTRACT: Aim: Ankle sprains are different in severity and may cause a disturbance in function and quality of life. In this study, we present quality of life changes after ankle sprain in the acute posttraumatic period and their correlation with ankle sprain severity and demographic characteristics of the patients. Materials-Methods: Seventy eight patients, 18 to 60 years old, with second-degree ankle sprain participated in this study. Ankle swelling was evaluated with volumetric method and ankle pain with visual analog scale on the day of injury and the tenth posttraumatic day. The quality of their lives was also evaluated using SF-36 questionnaire before injury, and the first ten days following injury. All patients were treated with RICE protocol. Results: Ankle swelling and ankle pain were decreased in all patients (p <0.001) the tenth post-traumatic day. Their quality of life deteriorated after injury. Quality of life changes was not in correlation with ankle sprain edema and pain, but it was in correlation with patient's age. Conclusions: Quality of life is clearly affected after ankle sprains in the acute posttraumatic period. Quality of life changes are not affected by ankle sprains edema and pain. These findings should be taken into consideration in the treatment of ankle sprains and disability time, as well as the patient’s age, which also affects the quality of life after ankle sprain.
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