Secretory carcinoma of the breast. Cancer

Cancer (Impact Factor: 4.89). 05/1980; 45(9):2404-13. DOI: 10.1002/1097-0142(19800501)45:9<2404::AID-CNCR2820450928>3.0.CO;2-8
Source: PubMed


Nineteen examples of a very rare type of carcinoma of the breast have been studied. The carcinoma is unusual in that it has exaggerated secretory features previously reported only (with one exception) in juveniles. But not all the patients in our series were juveniles; they ranged in age from 9 to 69 years (median age, 25 years). Six were 30 years of age or older. Eighteen patients were female and 1 was a 9-year-old boy. Treatment varied from local excision of the tumor to radical mastectomy. Four of the 11 patients who had axillary node dissection had metastatic deposits showing the same secretory features as the primary neoplasm. One of these 4 patients, a 25-year-old woman, died within ten months with disseminated tumor. Because this distinctive pattern of carcinoma is not limited to children and adolescents, we propose that it be called "secretory carcinoma." Since, of the 19 patients, 4 (21%) had axillary node metastases and 1 (5%) died with disseminated tumor, an extended simple mastectomy is recommended as the initial treatment for patients more than 20 years of age.

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    • "Secretory carcinoma was first reported in children and the older literature identified the disease by the name of juvenile breast carcinoma. However, after the review by Tavassoli and Norris [3], it was recognised that it may occur in adult patients as well. Recently, the tumor was found to be associated with a distinct ETV6-NTRK3 mutation which confers the tumor proliferative and survival advantage. "
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    ABSTRACT: Secretory carcinoma of the breast is an extremely rare subtype of breast cancer characterized by intracellular or extracellular secretion and granular eosinophilic cytoplasm of the neoplastic cells. The disease which was considered to be predominant in younger age group has been recognized in adult population too and tends to show slow growth and indolent behavior. The disease occurs preferentially in females and only 27 cases have been reported amongst males. An optimal treatment for the disease subtype has been debated because of the paucity of data. We report two cases (one female and one male) of this rare disease that underwent treatment at our institution.
    Full-text · Article · Aug 2015 · Case Reports in Oncological Medicine
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    • "It was initially termed juvenile breast carcinoma by McDivitt and Stewart (2) in 1966 as they reported seven cases of secretory carcinoma which occurred exclusively in young children with an average age of nine years. Subsequent studies have reported secretory carcinoma in adults, thus the disease was re-termed secretory breast carcinoma by Tavassoli and Norris (3) based on the histopathological characteristics of the tumor, with cells containing a vacuolated cytoplasm and the presence of intracellular and extracellular secretory material (4). "
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    ABSTRACT: Secretory breast carcinoma is a very rare and distinct subtype of breast cancer, characterized by the presence of intracellular and extracellular secretory material. Secretory breast carcinoma has a good clinical outcome and systemic involvement is rare. The majority of studies of this tumor have been case reports or separate analyses, and due to the rarity of these tumors, it has been difficult to fully elucidate their characteristics and define optimal treatment strategies. To add to the current knowledge of secretory breast carcinoma, the present study reports three cases of secretory breast carcinoma in patients of different ages, and with different hormone receptor statuses and treatment methods. The present study identified that each patient with secretory breast carcinoma may present with different symptoms and clinical characteristics. Therefore, therapeutic options should be selected based on the overall status of the patient and the characteristics of this rare disease.
    Full-text · Article · Aug 2014 · Oncology letters
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    • "SC was initially reported in children and young girls, and was named juvenile carcinoma.1 Subsequently, cases in adult females have increasingly been reported. Tavassoli et al.4,5 reported that secretory carcinoma has been found in patients aged from 3 to 87 years of age (median 25 years). Ozguroglu et al.6 reported that most (approx. "
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    ABSTRACT: We report a very rare case of extensive ductal carcinoma in situ (DCIS) of the breast with secretory features in a 30-year old Japanese woman. The patient presented with a nodule in the lower inner quadrant of the left breast measuring approximately 2-3 cm, accompanied by an irregular tumor shadow with segmental microcalcification on mammography. These findings suggested malignancy, and excisional biopsy was performed following core needle biopsy. Pathological diagnosis was that of DCIS with secretory features. A treatment plan of simple mastectomy and sentinel lymph node biopsy was chosen. Most previous reports have only described invasive secretory carcinoma of the breast. We have only been able to find 2 case reports of non-invasive secretory lesion in the English literature to date. Because the characteristics of this lesion are not widely known, we thought it important to share our findings.
    Full-text · Article · Oct 2012 · Rare tumors
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