Quantifying cortical atrophy

Journal of Neurology Neurosurgery & Psychiatry (Impact Factor: 6.81). 01/1985; 47(12):1314-8. DOI: 10.1136/jnnp.47.12.1314
Source: PubMed


Most of the methods of quantifying cortical atrophy that have been proposed involve the estimation of the volume of enlarged sulci in the cerebral cortex. The authors propose that the surface area of the sulci is a more valid measure of cortical atrophy, and describe a system for measuring the surface area of the cortex, and present data in support of the method's reliability and validity.

Download full-text


Available from: Ronald Yeo, Oct 14, 2014
  • Source

    Preview · Article ·
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Ventricular volume estimates and an index of cerebral atrophy were obtained from computerized axial tomography scans of patients with presenile or senile dementia of probable Alzheimer's type. These measures were used to examine the correlation between morphological brain change and performance on the Wechsler Adult Intelligence Scale (WAIS) and the Wechsler Memory Scale (WMS). Despite ventricular volumes in excess of 60% larger than normal, no significant correlations were found between ventricular size and WAIS or WMS performance. The index of pericerebral atrophy did correlate negatively with various WAIS measures, particularly Performance IQ, and some aspects of WMS performance. Results suggest that in Alzheimer's disease, pericerebral atrophy measures, but not ventricular dilation, correlate with intellectual decline and certain aspects of memory impairment.
    Preview · Article · Jul 1985 · Journal of Nervous & Mental Disease
  • [Show abstract] [Hide abstract]
    ABSTRACT: Neuropsychological assessment data from 138 Alzheimer's disease patients were cluster-analyzed to yield five separate subgroups. These clusters are best described as follows. Cluster I is a low-functioning subgroup characterized by severe generalized deficits (N = 25), cluster II is a subgroup characterized by a higher level of visual-spatial skills relative to the other groups (N = 39), cluster III (N = 21) and cluster IV (N = 42) are virtually indistinguishable in terms of verbal ability and memory, but do differ with regard to visual-spatial skills, and cluster V is a subgroup which presented with relatively better preserved verbal abilities (N = 11). Despite their different neuropsychological profiles, the subgroups did not differ significantly with regard to those complaints that were noted early in the course of the disease process. However, they were found to differ significantly with regard to the patients' educational backgrounds, the distribution of males and females, and the age of the patients at the time of onset of the disease. Analysis of the degree and lateralization of cortical atrophy using volumetric techniques suggested little relationship with neuropsychological examination results. Ventricular volume differences among the five subgroups were not found to be statistically significant after the effect of age had been partialled out. Results are discussed in relation to the multiple factors relating to brain structure and cognition in Alzheimer's disease.
    No preview · Article · Nov 1985 · Journal of Nervous & Mental Disease
Show more