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[2 cases of hydrocolpos caused by vaginal atresia associated with polydactyly]

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Purpose Diabetes mellitus (DM) leads to disorders such as cardiac hypertrophy, cardiac myocyte apoptosis, and cardiac fibrosis. Previous studies have shown that Lactobacillus reuteri GMNL-263 decreases cardiomyopathy by reducing inflammation. In this study, we investigated the potential benefit of GMNL-263 supplementation in treating diabetes-induced cardiomyocytes in rats with DM. Methods Five-week-old male Wistar rats were randomly divided into three groups, control, DM, and rats with DM treated with different dosages of L. reuteri GMNL-263. After undergoing treatment for 4 weeks, all rats were euthanized for further analysis. Results We observed that cardiac function and structure of rats with DM was rescued by GMNL-263. Activation of toll-like receptor 4 (TLR4)-related inflammatory, hypertrophic, and fibrotic signaling pathways in the hearts of rats with DM was reduced by treatment with GMNL-263. Conclusion Our findings demonstrate that GMNL-263 inhibited diabetes-induced cardiomyocytes via the repression of the TLR4 pathway. Moreover, these findings suggest that treatment with high-dose GMNL-263 could be a precautionary therapy for reducing the diabetes-induced cardiomyopathy. Graphical abstract
Chapter
Von der Gynäkologie des Erwachsenen unterscheidet sich die der Kinder bezüglich des Krankheitsspektrums durch folgende Besonderheiten: a) gehäuftes Vorkommen angeborener Anomalien und Mißbildungen des Genitale b) Unterschiede im histologischen Spektrum gutund bösartiger Tumoren c) Wachstumsbedingte Veränderungen, insbesondere Reifungsstörungen mit Akzeleration oder Retardation
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Mit den modernen bildgebenden Verfahren wie der Sonographie, der Computertomographie und der Kernspintomographie rückt die klinische Anatomie noch mehr ins Rampenlicht. Insbesondere die Darstellungsmöglichkeiten, die diese Verfahren ermöglichen — und hier ist die Kernspintomographie oder Magnetic resonance (MR) an erster Stelle zu nennen — setzt bei den Untersuchern räumliches Vorstellungsvermögen und eine fundierte Kenntnis der topographischen Anatomie voraus.
Article
This is the case of a white female newborn, child of a non-consanguinity married couple and a with negative family history of congenital defects in whom at 62 hours of born a dull, renitent tumor of almost 2 cm diameter, and protruding through the vaginae introitus when she cried was detected. Authors made a joint assessment with specialists in pediatric and urology surgery, gynecology-obstetrics, radiology, clinical genetics and cardiology. A hymenotomy was performed at 4 days of life voiding an abundant amount of seromucous secretion. Patient was discharged at 16 days and a satisfactory course. A clinical characterization of pathology was made offering an updated review on thus matter. Photographies from this case are showed.
Article
The uterovaginal obstruction anomalies in newborns are usually caused by urogenital sinus or cloacal malformations. We present the case of a newborn with an abdominal mass. The Magnetic Resonance (MRI) showed vaginal atresia associated to persistent urogenital sinus that caused massive hydrocolpoceles with a normal uterus and cervix. We consider that the information provided by the MRI is better than that obtained from the ultrasonography and computed tomography and that it represents the diagnostic method of choice prior to surgery.
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Diseases related to the urogenital system in both males and females, are common in clinical routine of small animal and represents important causes of morbidity and mortality in dogs and cats. Pyocolpos is a cystic dilatation of the vagina due to the accumulation of pus resulting from the genital tract obstruction. The main cause of obstruction is imperforate hymen, transverse vaginal membrane, or vaginal atresia.We present a case of a three-year-old female Pinscher with a history of constipation for four days, even after administration of laxatives and enema, and estrus for ten days without a report of cover. Physical examinations were performed, which revealed increased abdominal size. Ultrasound confirmed the presence of large amounts of vaginal fluid. Exploratory laparotomy was performed, which confirmed the diagnosis of pyocolpos. Although pyocolpos is a rare congenital malformation in female domestic animals, this report of its existence underscores the importance of more accurate clinical research when increased abdominal size is noted by veterinarians.
Article
Two cases of hematocolpometra, due to imperforate hymen of 15- and 16-year-old girls are presented. The diagnosis was based on computed tomography of the pelvis with contrast given per os, intravenously and per rectum, as well as ultrasound scan of uterus and vagina.
Article
Hydrocolpos is characterized by a vaginal accumulation of cervical and vaginal secretions. It often occurs in newborn child and infant. Imperforate hymen is frequently associated; in rare instances, complete higher vaginal diaphragm or partial vaginal atresia is diagnosed. Hydrocolpos can be treated by hymenectomy using imperforate hymen. Because of additional malformation, the treatment can be more complex for vaginal obstruction. The authors report a series of four patients with hydrocolpos: three neonates and one 2-month old infant. Ultrasonography confirmed the physical findings. Three patients with imperforate hymen underwent hymenectomy in X. The fourth which had a virginal atresia and pyocolpos drainage was treated using celioscopy. The three first patients outcome was favorable except for the patient with pyocolpos who died with septicemia.
Article
Hydrometrocolpos (HMC) and post-axial polydactyly (PAP) are common to both McKusick-Kaufman syndrome (MKS) and Bardet-Biedl syndrome (BBS). We review reported cases of MKS and BBS presenting with HMC and PAP early in life to determine if there are clinical features that allow discrimination between the two syndromes as the primary features of retinitis pigmentosa, obesity, learning disability in BBS are age-dependent. We did not find any phenotypic features that allowed reliable differentiation between the two syndromes in the neonatal period. However, uterine, ovarian, and fallopian tube anomalies are more common in BBS patients, and it may be that these clinical features prove to be useful discriminating features. We conclude that sporadic female infants with HMC and PAP cannot be diagnosed with MKS until at least age 5 years and that monitoring for the complications of BBS should be performed in these patients. Am. J. Med. Genet. 95:208–215, 2000. Published 2000 Wiley-Liss, Inc.
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