A 10-month-old infant with hypoplasia of the intestinal mucosa had the fat overload syndrome develop while receiving intravenous fat emulsion at a dosage of 5 g/kg/day of fat for five weeks. This syndrome was characterized by fever, jaundice, easy bruisability, increased levels of serum transaminases, conjugated hyperbilirubinemia, and abnormal results of clotting studies. Management consisted of withdrawal of parenteral nutrition for 72 hours, followed by gradual reinstitution of protein and subsequent introduction of fat at a lower dosage.
"High doses of lipid in the serum can result in a picture similar to hyper viscosity syndrome or fat overload syndrome. The neonatal population may have the highest risk of medication errorin apart because of the neonates immature physiologic developmentand according to MEDMARX, a national, internetaccessible medication error reporting program owned and operated by the United State Pharmacopeia many of these errors were the result of the nurses misinterpretation of the modes (i.e., time, volume or rate) on the infusion device or by not recognizing the decimal point on the device's display panel. Single plasma exchange used in adult for the treatment of accidental bolus of PN but there is a limited literature regarding its use in infants. "
[Show abstract][Hide abstract] ABSTRACT: This is one of a series of clinical guidelines. They represent a consensus statement dealing with optimum patient care in significant clinical areas. The statement has been prepared by the Patient Care Committee, with the advice of other experts and with peer review. As with all such guidelines, they should be interpreted in a nondogmatic manner, so as not to exclude other therapies or opinions in any particular situation. Based on present knowledge, limited at times, future modifications or other changes in these guidelines may be necessary.
No preview · Article · Mar 1989 · Digestive Diseases and Sciences
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