Oral glucosamine sulphate in the management of arthrosis: Report on a multi-centre open investigation in Portugal

Pharmatherapeutica 02/1982; 3(3):157-68.
Source: PubMed


An open study was carried out by 252 doctors throughout Portugal to assess the effectiveness and tolerability of oral glucosamine sulphate in the treatment of arthrosis. Patients received 1.5 g daily in 3 divided doses over a mean period of 50 +/- 14 days. The results from 1208 patients were analyzed and showed that the symptoms of pain at rest, on standing and on exercise and limited active and passive movements improved steadily through the treatment period. The improvement obtained lasted for a period of 6 to 12 weeks after the end of treatment. Objective therapeutic efficacy was rated by the doctors as 'good' in 59% of patients, and 'sufficient' in a further 36%. These results were significantly better than those obtained with previous treatments (except for injectable glucosamine) in the same patients. Sex, age, localization of arthrosis, concomitant illnesses or concomitant treatments did not influence the frequency of responders to treatment. Oral glucosamine was fully tolerated by 86% of patients, a significantly larger proportion than that reported with other previous treatments and approached only by injectable glucosamine. The onset of possible side-effects was significantly related to pre-existing gastro-intestinal disorders and related treatments, and to concomitant diuretic treatment.

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Available from: Angelo Bignamini, Jun 06, 2014
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    • "In the remaining 12 % of the study population, the reported adverse effects were generally mild and predominantly affected the gastrointestinal tract (e.g., epigastric pain, heartburn, and diarrhea). All the reported complaints were reversible with discontinuation of GS [52]. While some questions were raised regarding the role of glucosamine in glucose metabolism [53] and the possibility of increased insulin resistance, a detailed review of scientific studies performed with GS ruled out this possibility and re-emphasized the safety of short- and long-term use of GS [54]. "
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    ABSTRACT: Over the last 20 years, several studies have investigated the ability of glucosamine sulfate to improve the symptoms (pain and function) and to delay the structural progression of osteoarthritis. There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, is able to significantly reduce the symptoms of osteoarthritis in the lower limbs. This dose of glucosamine sulfate has also been shown, in two independent studies, to prevent the joint space narrowing observed at the femorotibial compartment in patients with mild-to-moderate knee osteoarthritis. This effect also translated into a 50 % reduction in the incidence of osteoarthritis-related surgery of the lower limbs during a 5-year period following the withdrawal of the treatment. Some discrepancies have been described between the results of studies performed with a patent-protected formulation of glucosamine sulfate distributed as a drug and those having used glucosamine preparations purchased from global suppliers, packaged, and sold over-the-counter as nutritional supplements.
    Full-text · Article · Mar 2012 · Rheumatology International
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    • "N-Acetyl-D-glucosamine (GlcNAc) has been a focusing material for the improvement of osteoarthritis as well as Dglucosamine (GlcN), which has attracted much attention owing to its therapeutic activity in osteoarthritis and been evaluated as a food supplement (Crolle & D'Este, 1980; Drovanti, Bignamini, & Rovati, 1980; Kajimoto et al., 1998; Kim & Conrad, 1974; Setnikar, Giacchetti, & Zanolo, 1986; Setnikar, Palumbo, Canali, & Zanolo, 1993; Tapadinhas, Rivera, & Bignamini, 1982; Vaz, 1982). Although sulfate and hydrochloride salts of GlcN are already commercialized for this disease, these are not suitable for oral administration owing to its bitter taste. "
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    ABSTRACT: N-Acetyl-d-glucosamine (GlcNAc) was produced from chitin by use of crude enzyme preparations. The efficient production of GlcNAc by cellulases derived from Trichoderma viride (T) and Acremonium cellulolyticus (A) was observed by HPLC analysis compared to lipase, hemicellulase, and pectinase. β-Chitin showed higher degradability than α-chitin when using cellulase T. The optimum pH of cellulase T was 4.0 on the hydrolysis of β-chitin. The yield of GlcNAc was enhanced by mixing of cellulase T and A.
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    • "● Significant improvement of pain and movement limitation in GS group throughout the 6 weeks (P ϭ .012) ● Improvement maintained through the 2-week follow-up Tapadinhas et al, 65 1982 1208 Patients (516 men, 692 women) ● Physician objective and subjective assessment All subjects received 1.5 g of oral GS for 6–8 weeks ● Objective assessment of therapeutic efficacy: 58.7% good, 36.0% sufficient, 5.3% insuffi- cient ● Concomitant illness affected GS effectiveness ● Significant reduction in overall intensity of articular symptoms during treatment (P Ͻ .001) "
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    ABSTRACT: To refresh the athletic trainer's knowledge of articular cartilage biomechanics, physiology, and structure and explore the role of glucosamine sulfate in treating articular cartilage pathologic conditions, including supplementation methods and clinical outcomes. We searched MEDLINE from 1989 through 2000 and SPORT Discus from 1975 through 2000 using the following key words: glucosamine sulfate, articular cartilage, osteoarthritis, and proteoglycans. Articular cartilage functions as a wear-resistant, smooth, nearly frictionless, load-bearing surface. Glucosamine sulfate can be thought of as a building block that helps restore the proteoglycan-rich extracellular matrix and thus balance articular cartilage catabolism and anabolism. Beneficial clinical effects of glucosamine sulfate in the osteoarthritic population have been documented. However, the use of glucosamine sulfate for athletic articular cartilage injuries is unproved. Clinical studies indicate that glucosamine sulfate has been shown to be a safe and relatively effective treatment for osteoarthritis. However, no evidence to date supports or refutes a carryover effect to the athletic population and the injuries that occur in sport.
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