Wang, W. et al. Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. Science 269,1588-1590

Department of Microbiology, University of Virginia, Charlottesville 22908, USA.
Science (Impact Factor: 33.61). 10/1995; 269(5230):1588-90.
Source: PubMed


H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.

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    • "could be reactivated ex vivo from the peripheral blood before and after AP1903 infusion, three of the four patients receiving AP1903 had disease relapse, compared to only one of six patients who were not so treated, raising the concern that elimination of alloreactive cells would hamper GVL (Zhou et al., 2014), because of the potential co-expression of minor histocompatibility antigens on hematopoietic and non-hematopoietic tissues (de Bueger et al., 1992; Wang et al., 1995; Meadows et al., 1997; Vogt et al., 2000). The relative contribution of alloreactive cells, as compared with TAAs specific T cells is not difficult to quantify, however since most TAAs are aberrantly expressed self-proteins resulting in T cells with low-affinity TCR, it is possible that the alloreactive component is more determinant for GvL. "
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    • "The evidence presently available suggests that JARID1D contributes to rejection of male tissues by female transplant recipients.99 There is limited research on the association between JARID1D and cancer. "
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    • ", but until a few years ago only two mHA had been identified: the male-specific H–Y transplantation antigen, derived from a gene located on the short arm of the Y chromosome [13] and the HA-1 antigen, an HLA-A2-restricted mHA [14]. The initiating event in GVHD is the recognition of target antigens on host cells by donor-derived immunocompetent cells. "
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