INTRODUCTION Urinary stone disease is a common disorder estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males and 47-60% in females. Urolithiasis, one of the oldest, painfull aliments of the urinary tract disorder, wide spread among men. Calcium oxalate (CaOx) is the primary constituent of the majority of stones in the urinary system of patients with urolithiasis.  Approximately 80% of stones are composed of calcium oxalate (Caox) and calcium phosphate (CaP); 10% of struvite, 9% of uric acid (UA) and remaining 1% are composed of cystine.  The incidence of urolithiasis in world – wide is quite high and there is no satisfactory mode of treatment. Combinations of surgical and medical approach using percutaneous nephrolithotomy (PCNL), extracorporeal shock wave lithotripsy (ESWL) are employed to manage urolithiasis. All these treatments are relatively costly, painful and cause undesirable side effects such as hemorrhage, hypertension, tubular necrosis and subsequent fibrosis of the kidney leading to cell injury and recurrence of renal stone formation.  So it is worthwhile to look for an alternative for the management of urolithasis, and hence medicinal plants are adopted. Amarathus viridis linn,  is an annual herb, erect, 10 to 75 cm stem, slender, branched, angular, glabrous, long petiolate, lamina deltoidovate to rhomboid-oblong, flowers are green, axillary or terminal, often paniculate spikes. Amarathus viridis contains chemical constituents, [4-6] like carbohydrates, proteins, calcium, phosphorus, iron, magnesium, sodium, potassium and zinc, thiamine, riboflavin, niacin, flavonoids like rutin and quercetin. The Amarathus viridis roots contain sterol, used in snake bite; the leaves contain fatty acid like palmitic acid, carotenoids, amino acids. Traditionally [7, 8] Amarathus viridis is used as anti-inflammatory agent, vermifuge, diuretic, antirheumatic, antiulcer, analgesic, antiemetic, laxative, antilerotic, respiratory problems, eye treatment and for asthma and antiviral activity. The whole plant is used for the treatment of pain and fever. MATERIALS AND METHODS Drugs/Chemicals/Reagents All the chemicals (Ethylene glycol, Cystone, Creatinine estimation kit, Uric acid estimation kit, Electrolyte estimation kit) used were of analytical grade purchased from S. D. fine chemicals Pvt. Ltd. Bangalore. All the biochemical kit used in the study was purchased from span Diagnostics Pvt. Ltd, Surat, India. Plant Material The roots of plant Amarathus viridis was collected from Vellore and authenticated. The plant part was shade dried and crushed at room temperature. The powder obtained was extracted with distilled water. The extract obtained was stored in an air tight container for future use.