Elevated D dimer in the lungs and blood of patients with sarcoidosis

Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia, United States
Chest (Impact Factor: 7.48). 05/1993; 103(4):1100-6. DOI: 10.1378/chest.103.4.1100
Source: PubMed


The hypothesis of this study was that D dimer, a specific degradation product of cross-linked fibrin, would be increased in the bronchoalveolar lavage (BAL) fluids of patients with sarcoidosis and that it would be related to other BAL parameters of disease activity. Eight of 10 sarcoidosis patients but none of 18 healthy volunteers had detectable BAL D dimer by enzyme immunoassay. Autoradiography revealed the presence of fibrinogen and D dimer in the BAL fluids from sarcoidosis patients. Bronchoalveolar lavage D dimer levels in sarcoidosis patients correlated with total BAL cells per milliliter, lymphocytes per milliliter, and total protein level, but not macrophages per milliliter. The D dimer in the BAL fluids from sarcoidosis patients did not correlate with D dimer in the blood. Our findings indicate that BAL D dimer parallels directly the lymphocytic alveolitis that characterizes pulmonary sarcoidosis.

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Available from: Gerald W Staton, Sep 18, 2015
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    • "Several parameters have been thoroughly evaluated to serve as markers for pulmonary fibrosis (type III procollagen peptide, collagenase, hyaluronan, and fibrinogen and its degradation products) (Bjemer et al,1991;Mornex et al,1994;Pohl et al,1992;O'Connor et al,1989;Perez et al,1993;Schaberg et al,1994). The problem encountered with this concept is that none of the named markers can differentiate between pathological fibrosis and normal tissue turnover in inflammation, as demonstrated by the fact that some markers correlate with parameters of alveolitis (Perez et al,1993), although conflicting results have been obtained in longitudinal studies (Pohl et al,1992;O'Connor et al,1989). "

    Full-text · Chapter · Oct 2011
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    • "D-dimer in BAL fluid also supports the diagnosis of sarcoidosis. One observational study found that eight out of ten patients with sarcoidosis had detectable D-dimer in their BAL fluid, compared to none of 18 healthy controls [15]. "
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    ABSTRACT: We would like to report a case of a 29-year-old male patient who presented with multiple lymphadenopathy and vague symptoms of low grade fever, cough, weight loss, rashes, vomiting, dry eyes and dry mouth. Physical examination revealed submandibular lymphadenopathy, vasculitic rashes over both lower limbs, and parotid gland enlargement. Blood investigations showed mild anemia with leukocytosis, predominantly eosinophilia and high erythrocyte sedimentation rate and C-reactive protein. Computed tomography of the neck, thorax and abdomen showed bilateral submandibular, submental adenopathy, mediastinal and para-aortic lymphadenopathy with generalized reticulonodular densities in both lower lobes. There were hepatomegaly and bilateral enlarged kidneys with renal cyst. Histopathological examination from the cervical lymph node later revealed non-caseating granuloma, consistent of sarcoidosis. Patient responded well to prednisolone 50 mg daily with subsequent reduction in the size of cervical lymphadenopathy and parotid swelling. Keywords Lymphadenopathy; Granuloma; Sjogren; Sarcoidosis
    Full-text · Article · Dec 2010 · Journal of Clinical Medicine Research

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